Fluoro-Gold tracing after chronic constriction injury of rat sciatic nerve

Daša Čížková, Stanislava Jergová, Nadežda Lukáčová, Martin Maršala, Milan Čížek, Jozef Maršala

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study we have used Fluoro-Gold (FG) to retrogradely label primary sensory neurons in dorsal root ganglia (DRG) and motoneurons in ventral horn following chronic constriction injury of sciatic nerve (CCI). The neuropathic animals with fully developed tactile allodynia revealed a significant decrease of FG-labeled neurons in DRG L4-L5, three weeks after nerve-ligation. No such changes were detected in the DRG of sham-operated rats. The FG labeling in the motoneurons throughout L4-L6 spinal cord segments remained unchanged in both sham-operated and neuropathic groups. These data suggest that remodeling processes induced by CCI affect first of all the sensory pathways throughout the corresponding DRG.

Original languageEnglish (US)
Pages (from-to)319-323
Number of pages5
JournalBiologia - Section Cellular and Molecular Biology
Volume60
Issue number3
StatePublished - May 2005
Externally publishedYes

Keywords

  • Dorsal root ganglia
  • Fluorogold
  • Neuropathic pain
  • Spinal cord

ASJC Scopus subject areas

  • Genetics
  • Environmental Science(all)
  • Clinical Biochemistry
  • Cell Biology

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