Abstract
The fluorescent analogs of neurotransmitters and other neuroactive compounds are important molecular tools. When combined with imaging and detection platforms, they can provide superb spatial and temporal resolution of biomolecular processes governing neurotransmitters. This chapter focuses on small-molecule neurotransmitters and their fluorescent analogs or replacements, and provides a brief review of the basic structure of neurotransmitters as well as the biomacromolecules that regulate their function. The design and synthesis of new generation fluorescent analogs of neurotransmitters has produced probes with improved optical properties such as longer wavelength absorption and emission. Fluorescent analogs have played a key role in exploring the structure and function of neurotransmitter transporters, receptors as well as the enzymes responsible for neurotransmitter metabolism. Fluorescent analogs of neurotransmitters also serve as substrates for a number of monoamine transporters (MATs) demonstrating the functional elasticity of these important biomacromolecules.
| Original language | English (US) |
|---|---|
| Title of host publication | Fluorescent Analogs of Biomolecular Building Blocks |
| Subtitle of host publication | Design and Applications |
| Publisher | wiley |
| Pages | 393-407 |
| Number of pages | 15 |
| ISBN (Electronic) | 9781119179320 |
| ISBN (Print) | 9781118175866 |
| DOIs | |
| State | Published - Apr 1 2016 |
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Keywords
- Biomacromolecules
- Enzyme substrates
- Fluorescent neurotransmitter analogs
- Monoamine transporters
- Neurotransmitter metabolism
- Optical properties
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Fluorescent Neurotransmitter Analogs. / Wilson, James N.
Fluorescent Analogs of Biomolecular Building Blocks: Design and Applications. wiley, 2016. p. 393-407.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Fluorescent Neurotransmitter Analogs
AU - Wilson, James N
PY - 2016/4/1
Y1 - 2016/4/1
N2 - The fluorescent analogs of neurotransmitters and other neuroactive compounds are important molecular tools. When combined with imaging and detection platforms, they can provide superb spatial and temporal resolution of biomolecular processes governing neurotransmitters. This chapter focuses on small-molecule neurotransmitters and their fluorescent analogs or replacements, and provides a brief review of the basic structure of neurotransmitters as well as the biomacromolecules that regulate their function. The design and synthesis of new generation fluorescent analogs of neurotransmitters has produced probes with improved optical properties such as longer wavelength absorption and emission. Fluorescent analogs have played a key role in exploring the structure and function of neurotransmitter transporters, receptors as well as the enzymes responsible for neurotransmitter metabolism. Fluorescent analogs of neurotransmitters also serve as substrates for a number of monoamine transporters (MATs) demonstrating the functional elasticity of these important biomacromolecules.
AB - The fluorescent analogs of neurotransmitters and other neuroactive compounds are important molecular tools. When combined with imaging and detection platforms, they can provide superb spatial and temporal resolution of biomolecular processes governing neurotransmitters. This chapter focuses on small-molecule neurotransmitters and their fluorescent analogs or replacements, and provides a brief review of the basic structure of neurotransmitters as well as the biomacromolecules that regulate their function. The design and synthesis of new generation fluorescent analogs of neurotransmitters has produced probes with improved optical properties such as longer wavelength absorption and emission. Fluorescent analogs have played a key role in exploring the structure and function of neurotransmitter transporters, receptors as well as the enzymes responsible for neurotransmitter metabolism. Fluorescent analogs of neurotransmitters also serve as substrates for a number of monoamine transporters (MATs) demonstrating the functional elasticity of these important biomacromolecules.
KW - Biomacromolecules
KW - Enzyme substrates
KW - Fluorescent neurotransmitter analogs
KW - Monoamine transporters
KW - Neurotransmitter metabolism
KW - Optical properties
UR - http://www.scopus.com/inward/record.url?scp=85019562683&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019562683&partnerID=8YFLogxK
U2 - 10.1002/9781119179320.ch17
DO - 10.1002/9781119179320.ch17
M3 - Chapter
SN - 9781118175866
SP - 393
EP - 407
BT - Fluorescent Analogs of Biomolecular Building Blocks
PB - wiley
ER -