Fluorescent Neurotransmitter Analogs

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The fluorescent analogs of neurotransmitters and other neuroactive compounds are important molecular tools. When combined with imaging and detection platforms, they can provide superb spatial and temporal resolution of biomolecular processes governing neurotransmitters. This chapter focuses on small-molecule neurotransmitters and their fluorescent analogs or replacements, and provides a brief review of the basic structure of neurotransmitters as well as the biomacromolecules that regulate their function. The design and synthesis of new generation fluorescent analogs of neurotransmitters has produced probes with improved optical properties such as longer wavelength absorption and emission. Fluorescent analogs have played a key role in exploring the structure and function of neurotransmitter transporters, receptors as well as the enzymes responsible for neurotransmitter metabolism. Fluorescent analogs of neurotransmitters also serve as substrates for a number of monoamine transporters (MATs) demonstrating the functional elasticity of these important biomacromolecules.

Original languageEnglish (US)
Title of host publicationFluorescent Analogs of Biomolecular Building Blocks
Subtitle of host publicationDesign and Applications
Publisherwiley
Pages393-407
Number of pages15
ISBN (Electronic)9781119179320
ISBN (Print)9781118175866
DOIs
StatePublished - Apr 1 2016

Keywords

  • Biomacromolecules
  • Enzyme substrates
  • Fluorescent neurotransmitter analogs
  • Monoamine transporters
  • Neurotransmitter metabolism
  • Optical properties

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Wilson, J. N. (2016). Fluorescent Neurotransmitter Analogs. In Fluorescent Analogs of Biomolecular Building Blocks: Design and Applications (pp. 393-407). wiley. https://doi.org/10.1002/9781119179320.ch17