Fluorescence glucose detection: Advances toward the ideal in vivo biosensor

Elizabeth A. Moschou, Bethel V. Sharma, Sapna K. Deo, Sylvia Daunert

Research output: Contribution to journalReview articlepeer-review

140 Scopus citations

Abstract

The importance of glucose monitoring for in vivo as well as for ex vivo applications has driven a vast number of scientific groups to pursue the development of an advanced glucose sensor. Such a sensor must be robust, versatile, and capable of the long-term, accurate and reproducible detection of glucose levels in various testing media. Among the different configurations and signal transduction mechanisms used, fluorescence-based glucose sensors constitute a growing class of glucose sensors represented by an increasing number of significant contributions to the field over the last few years. This manuscript reviews the progress in the development of fluorescence based glucose sensors resulting from the advances in the design of new receptor systems for glucose recognition and the utilization of new fluorescence transduction schemes.

Original languageEnglish (US)
Pages (from-to)535-547
Number of pages13
JournalJournal of Fluorescence
Volume14
Issue number5
DOIs
StatePublished - Sep 1 2004
Externally publishedYes

Keywords

  • Detection
  • Fluorescence
  • Glucose
  • In vivo
  • Sensor

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry

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