Fluorescein angiography findings in children with congenital Zika syndrome

Camila V. Ventura, Adriana L. Gois, Bárbara O. Freire, Danielle C. De Almeida, Leslie D. MacKeen, Marcelo C. Ventura Filho, Audina M. Berrocal, R. V. Paul Chan, Rubens Belfort, Mauricio Maia, Liana O. Ventura

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


BACKGROUND AND OBJECTIVE: To evaluate the retinal and vasculature changes in infants with congenital Zika syndrome (CZS) using fluorescein angiography (FA). PATIENTS AND METHODS: This consecutive case series included six infants with CZS. FA and color fundus imaging were performed under general anesthesia in both eyes of all infants using a contact widefield digital imaging system. All color fundus images were obtained using a 130° field of view lens, and the FA images were captured using either a 130° or 80° field of view lens. The immunoglobulin M antibody capture enzyme-linked immunosorbent assay was positive for Zika virus in the cerebrospinal fluid samples of all infants. Other congenital infections were ruled out. RESULTS: The mean ± standard deviation age of the infants at the time of examination was 1.4 years ± 0.1 years (range: 1.3 years to 1.5 years). Contact fundus photographs showed macular abnormalities in seven eyes (58%) and retinal vasculature changes in two eyes (17%). FA detected macular abnormalities in all 12 eyes (100%) and retinal vasculature changes in five eyes (42%). The main retinal vasculature changes were peripheral avascularity in five eyes (42%) and microvasculature abnormalities in three eyes (25%). CONCLUSION: FA may be an important tool for detecting subtle macular and retinal vasculature changes in CZS.

Original languageEnglish (US)
Pages (from-to)702-708
Number of pages7
JournalOphthalmic Surgery Lasers and Imaging Retina
Issue number11
StatePublished - 2019

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology


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