TY - JOUR
T1 - Flumazenil reduces the duration of thiopentone but not of propofol anaesthesia in humans
AU - Fassoulaki, Argyro
AU - Sarantopoulos, Constantine
AU - Papilas, Konstantine
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 1993/1
Y1 - 1993/1
N2 - The effect of flumazenil (F) on the duration of anaesthesia produced by a single dose of thiopentone (T) and propofol (P) was investigated in a placebo-controlled double-blind trial. Eighty-four patients anaesthetized with N2O in O2 and either thiopentone 7 mg · kg-1 or propofol 3 mg · kg-1 for minor gynaecological procedures were studied. Patients were randomly allocated to pretreatment with either 0.5 mg of flumazenil (F) or 5 ml of normal saline (NS) in one of the following groups: T/NS, T/F, P/NS, or P/F. Anaesthetic requirements were assessed by recording the time between the injection of anaesthetic and the first movement observed during the procedure. The time elapsed from the administration of thiopentone to the first movement was 6.5 ± 1.6 min for the T/NS group and 5.3 ± 2.4 min for the T/F group (P < 0.05). The first movement after propofol administration was observed at 7.0 ± 2.2 min in the P/NS group and at 7.1 ± 4.5 min in the P/F group (NS). These data suggest that pretreatment with 0.5 mg of flumazenil iv reduces the duration of thiopentone but not of propofol anaesthesia.
AB - The effect of flumazenil (F) on the duration of anaesthesia produced by a single dose of thiopentone (T) and propofol (P) was investigated in a placebo-controlled double-blind trial. Eighty-four patients anaesthetized with N2O in O2 and either thiopentone 7 mg · kg-1 or propofol 3 mg · kg-1 for minor gynaecological procedures were studied. Patients were randomly allocated to pretreatment with either 0.5 mg of flumazenil (F) or 5 ml of normal saline (NS) in one of the following groups: T/NS, T/F, P/NS, or P/F. Anaesthetic requirements were assessed by recording the time between the injection of anaesthetic and the first movement observed during the procedure. The time elapsed from the administration of thiopentone to the first movement was 6.5 ± 1.6 min for the T/NS group and 5.3 ± 2.4 min for the T/F group (P < 0.05). The first movement after propofol administration was observed at 7.0 ± 2.2 min in the P/NS group and at 7.1 ± 4.5 min in the P/F group (NS). These data suggest that pretreatment with 0.5 mg of flumazenil iv reduces the duration of thiopentone but not of propofol anaesthesia.
KW - anaesthetics intravenous: propofol, thiopentone
KW - antagonists: benzodiazepines, flumazenil
KW - potency: anaesthetic
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U2 - 10.1007/BF03009310
DO - 10.1007/BF03009310
M3 - Article
C2 - 8425236
AN - SCOPUS:0027526428
VL - 40
SP - 10
EP - 12
JO - Canadian journal of anaesthesia = Journal canadien d'anesthésie
JF - Canadian journal of anaesthesia = Journal canadien d'anesthésie
SN - 0008-2856
IS - 1
ER -