TY - JOUR
T1 - Fluconazole prophylaxis in critically ill trauma intensive care unit patients
AU - Munshi, Imtiaz
AU - Steeman, Danny
AU - Parra-Oavia, Eduarde
AU - Erbefla, Jose
AU - Siva, Rogelio
AU - Morejon, Ortando
AU - Kkton, Orlando
AU - Namias, Nick
PY - 1998
Y1 - 1998
N2 - Introduction: To investigate the efficacy of fluconazote as prophylaxis on the incidence of secondary fungal infections in critically ill trauma intensive care unit (TICU) patients receiving broad spectrum antibiotics and to assess the development of resistant fungal species to fluconazote Methods: Descriptive, prospective study, over 38 months, involving 328 TICU patients placed on broad spectrum antibiotics. AI patients received 200 mg/day enterai dose fluconazote for the duration of broad spectrum antibiotic usage. Pre-and post-fluconazole cultures are obtained. Results: 328 TICU patients were placed on broad spectrum antibiotics and subsequent floconazote prophylaxis. Distribution of fungal species while on fluconazote prophylaxis: Site C. albkans Non-C. a/ftcans Total blood 3 9 12 tracheal 5 13 18 urine 2 22 24 other 3 13 16 Total 13 57 70 12 patients developed fungemia. Non-Candfcte a/beans organisms accounted for over four times as many candidat infections. Conclusion: Fluconazote. at 200mg/day, for TICU patients receiving broad spectrum antibiotics, did not prevent the development of fungemia. Fungal species which developed were T. giabrata, C. tropicatis, and C. parapsetosis and not C. Krusei.
AB - Introduction: To investigate the efficacy of fluconazote as prophylaxis on the incidence of secondary fungal infections in critically ill trauma intensive care unit (TICU) patients receiving broad spectrum antibiotics and to assess the development of resistant fungal species to fluconazote Methods: Descriptive, prospective study, over 38 months, involving 328 TICU patients placed on broad spectrum antibiotics. AI patients received 200 mg/day enterai dose fluconazote for the duration of broad spectrum antibiotic usage. Pre-and post-fluconazole cultures are obtained. Results: 328 TICU patients were placed on broad spectrum antibiotics and subsequent floconazote prophylaxis. Distribution of fungal species while on fluconazote prophylaxis: Site C. albkans Non-C. a/ftcans Total blood 3 9 12 tracheal 5 13 18 urine 2 22 24 other 3 13 16 Total 13 57 70 12 patients developed fungemia. Non-Candfcte a/beans organisms accounted for over four times as many candidat infections. Conclusion: Fluconazote. at 200mg/day, for TICU patients receiving broad spectrum antibiotics, did not prevent the development of fungemia. Fungal species which developed were T. giabrata, C. tropicatis, and C. parapsetosis and not C. Krusei.
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U2 - 10.1097/00003246-199801001-00073
DO - 10.1097/00003246-199801001-00073
M3 - Article
AN - SCOPUS:33750259136
VL - 26
SP - A45
JO - Critical Care Medicine
JF - Critical Care Medicine
SN - 0090-3493
IS - 1 SUPPL.
ER -