Flow cytometry in radiation research

Past, present and future

George D. Wilson, Brian Marples

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Flow cytometry is an invaluable technique in research and clinical laboratories. The technique has been applied extensively to many areas of radiation research at both the experimental and clinical level. In the past few years, there has been a significant increase in the capabilities of modern flow cytometers to undertake multicolor analysis in a user-friendly manner. The developments in cytometric technology are being matched by the rapid development of new reagents, new fluorochromes and new platforms such as bead arrays. These developments are facilitating many new applications in both basic and clinical research that have relevance for many fields of biology, including radiation research. This review provides a historical overview of the application of flow cytometry to radiobiology and an update on how technology and reagents have changed and cites examples of new applications relevant to radiation researchers. In addition, some entirely new flow instrumentation is currently under development that has significant potential for applications in radiation research.

Original languageEnglish (US)
Pages (from-to)391-403
Number of pages13
JournalRadiation Research
Volume168
Issue number4
DOIs
StatePublished - Oct 1 2007
Externally publishedYes

Fingerprint

cytometry
Flow Cytometry
Radiation
Radiobiology
radiation
Research
reagents
radiobiology
Technology
biology
beads
Fluorescent Dyes
platforms
Research Design
Research Personnel

ASJC Scopus subject areas

  • Radiation
  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Flow cytometry in radiation research : Past, present and future. / Wilson, George D.; Marples, Brian.

In: Radiation Research, Vol. 168, No. 4, 01.10.2007, p. 391-403.

Research output: Contribution to journalReview article

@article{ab685ded5b2f4aeb8a21337de98a514d,
title = "Flow cytometry in radiation research: Past, present and future",
abstract = "Flow cytometry is an invaluable technique in research and clinical laboratories. The technique has been applied extensively to many areas of radiation research at both the experimental and clinical level. In the past few years, there has been a significant increase in the capabilities of modern flow cytometers to undertake multicolor analysis in a user-friendly manner. The developments in cytometric technology are being matched by the rapid development of new reagents, new fluorochromes and new platforms such as bead arrays. These developments are facilitating many new applications in both basic and clinical research that have relevance for many fields of biology, including radiation research. This review provides a historical overview of the application of flow cytometry to radiobiology and an update on how technology and reagents have changed and cites examples of new applications relevant to radiation researchers. In addition, some entirely new flow instrumentation is currently under development that has significant potential for applications in radiation research.",
author = "Wilson, {George D.} and Brian Marples",
year = "2007",
month = "10",
day = "1",
doi = "10.1667/RR1042.1",
language = "English (US)",
volume = "168",
pages = "391--403",
journal = "Radiation Research",
issn = "0033-7587",
publisher = "Radiation Research Society",
number = "4",

}

TY - JOUR

T1 - Flow cytometry in radiation research

T2 - Past, present and future

AU - Wilson, George D.

AU - Marples, Brian

PY - 2007/10/1

Y1 - 2007/10/1

N2 - Flow cytometry is an invaluable technique in research and clinical laboratories. The technique has been applied extensively to many areas of radiation research at both the experimental and clinical level. In the past few years, there has been a significant increase in the capabilities of modern flow cytometers to undertake multicolor analysis in a user-friendly manner. The developments in cytometric technology are being matched by the rapid development of new reagents, new fluorochromes and new platforms such as bead arrays. These developments are facilitating many new applications in both basic and clinical research that have relevance for many fields of biology, including radiation research. This review provides a historical overview of the application of flow cytometry to radiobiology and an update on how technology and reagents have changed and cites examples of new applications relevant to radiation researchers. In addition, some entirely new flow instrumentation is currently under development that has significant potential for applications in radiation research.

AB - Flow cytometry is an invaluable technique in research and clinical laboratories. The technique has been applied extensively to many areas of radiation research at both the experimental and clinical level. In the past few years, there has been a significant increase in the capabilities of modern flow cytometers to undertake multicolor analysis in a user-friendly manner. The developments in cytometric technology are being matched by the rapid development of new reagents, new fluorochromes and new platforms such as bead arrays. These developments are facilitating many new applications in both basic and clinical research that have relevance for many fields of biology, including radiation research. This review provides a historical overview of the application of flow cytometry to radiobiology and an update on how technology and reagents have changed and cites examples of new applications relevant to radiation researchers. In addition, some entirely new flow instrumentation is currently under development that has significant potential for applications in radiation research.

UR - http://www.scopus.com/inward/record.url?scp=35549008786&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35549008786&partnerID=8YFLogxK

U2 - 10.1667/RR1042.1

DO - 10.1667/RR1042.1

M3 - Review article

VL - 168

SP - 391

EP - 403

JO - Radiation Research

JF - Radiation Research

SN - 0033-7587

IS - 4

ER -