Flow Cytometric Studies on Modulation of Cellular Adriamycin Retention by Phenothiazines

Awtar Krishan; Antonieta Sauerteig; Larry L. Wellham

Flow Cytometric Studies on Modulation of Cellular Adriamycin Retention by Phenothiazines

Awtar Krishan, Antonieta Sauerteig, Larry L. Wellham

Pathology

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Phenothiazines (chlorpromazine and trifluoperazine) enhance the cellular retention and cytotoxicity of Adriamycin in P388/S and P388/R cells. Effects on the resistant cells are more pronounced than those on the sensitive cels. Multiparametric flow-cytometric determination of cellular Adriamycin fluorescence shows that the phenothiazine effects are not uniform in a cell population, and cells in later part of the cell cycle traverse (S and G₂/M), mitogen-stimulated lymphocytes (as compared to nonstimulated lymphocytes), and ascites (as compared to splenocytes) have greater sensitivity to phenothiazine effects on Adriamycin retention.

Original language	English (US)
Pages (from-to)	1046-1051
Number of pages	6
Journal	Cancer Research
Volume	45
Issue number	3
State	Published - Mar 1 1985

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Flow Cytometric Studies on Modulation of Cellular Adriamycin Retention by Phenothiazines",

abstract = "Phenothiazines (chlorpromazine and trifluoperazine) enhance the cellular retention and cytotoxicity of Adriamycin in P388/S and P388/R cells. Effects on the resistant cells are more pronounced than those on the sensitive cels. Multiparametric flow-cytometric determination of cellular Adriamycin fluorescence shows that the phenothiazine effects are not uniform in a cell population, and cells in later part of the cell cycle traverse (S and G2/M), mitogen-stimulated lymphocytes (as compared to nonstimulated lymphocytes), and ascites (as compared to splenocytes) have greater sensitivity to phenothiazine effects on Adriamycin retention.",

author = "Awtar Krishan and Antonieta Sauerteig and Wellham, {Larry L.}",

year = "1985",

month = mar,

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language = "English (US)",

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pages = "1046--1051",

journal = "Cancer Research",

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T1 - Flow Cytometric Studies on Modulation of Cellular Adriamycin Retention by Phenothiazines

AU - Krishan, Awtar

AU - Sauerteig, Antonieta

AU - Wellham, Larry L.

PY - 1985/3/1

Y1 - 1985/3/1

N2 - Phenothiazines (chlorpromazine and trifluoperazine) enhance the cellular retention and cytotoxicity of Adriamycin in P388/S and P388/R cells. Effects on the resistant cells are more pronounced than those on the sensitive cels. Multiparametric flow-cytometric determination of cellular Adriamycin fluorescence shows that the phenothiazine effects are not uniform in a cell population, and cells in later part of the cell cycle traverse (S and G2/M), mitogen-stimulated lymphocytes (as compared to nonstimulated lymphocytes), and ascites (as compared to splenocytes) have greater sensitivity to phenothiazine effects on Adriamycin retention.

AB - Phenothiazines (chlorpromazine and trifluoperazine) enhance the cellular retention and cytotoxicity of Adriamycin in P388/S and P388/R cells. Effects on the resistant cells are more pronounced than those on the sensitive cels. Multiparametric flow-cytometric determination of cellular Adriamycin fluorescence shows that the phenothiazine effects are not uniform in a cell population, and cells in later part of the cell cycle traverse (S and G2/M), mitogen-stimulated lymphocytes (as compared to nonstimulated lymphocytes), and ascites (as compared to splenocytes) have greater sensitivity to phenothiazine effects on Adriamycin retention.

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M3 - Article

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AN - SCOPUS:0021953802

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JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

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ER -

Flow Cytometric Studies on Modulation of Cellular Adriamycin Retention by Phenothiazines

Abstract

ASJC Scopus subject areas

UN SDGs

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