Abstract
Phenothiazines (chlorpromazine and trifluoperazine) enhance the cellular retention and cytotoxicity of Adriamycin in P388/S and P388/R cells. Effects on the resistant cells are more pronounced than those on the sensitive cels. Multiparametric flow-cytometric determination of cellular Adriamycin fluorescence shows that the phenothiazine effects are not uniform in a cell population, and cells in later part of the cell cycle traverse (S and G2/M), mitogen-stimulated lymphocytes (as compared to nonstimulated lymphocytes), and ascites (as compared to splenocytes) have greater sensitivity to phenothiazine effects on Adriamycin retention.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1046-1051 |
| Number of pages | 6 |
| Journal | Cancer Research |
| Volume | 45 |
| Issue number | 3 |
| State | Published - Mar 1 1985 |
ASJC Scopus subject areas
- Oncology
- Cancer Research
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Krishan, A., Sauerteig, A., & Wellham, L. L. (1985). Flow Cytometric Studies on Modulation of Cellular Adriamycin Retention by Phenothiazines. Cancer Research, 45(3), 1046-1051.