Abstract
Phenothiazines (chlorpromazine and trifluoperazine) enhance the cellular retention and cytotoxicity of Adriamycin in P388/S and P388/R cells. Effects on the resistant cells are more pronounced than those on the sensitive cels. Multiparametric flow-cytometric determination of cellular Adriamycin fluorescence shows that the phenothiazine effects are not uniform in a cell population, and cells in later part of the cell cycle traverse (S and G2/M), mitogen-stimulated lymphocytes (as compared to nonstimulated lymphocytes), and ascites (as compared to splenocytes) have greater sensitivity to phenothiazine effects on Adriamycin retention.
Original language | English (US) |
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Pages (from-to) | 1046-1051 |
Number of pages | 6 |
Journal | Cancer Research |
Volume | 45 |
Issue number | 3 |
State | Published - Mar 1 1985 |
ASJC Scopus subject areas
- Oncology
- Cancer Research