Abstract
Phenothiazines (chlorpromazine and trifluoperazine) enhance the cellular retention and cytotoxicity of Adriamycin in P388/S and P388/R cells. Effects on the resistant cells are more pronounced than those on the sensitive cels. Multiparametric flow-cytometric determination of cellular Adriamycin fluorescence shows that the phenothiazine effects are not uniform in a cell population, and cells in later part of the cell cycle traverse (S and G2/M), mitogen-stimulated lymphocytes (as compared to nonstimulated lymphocytes), and ascites (as compared to splenocytes) have greater sensitivity to phenothiazine effects on Adriamycin retention.
| Original language | English |
|---|---|
| Pages (from-to) | 1046-1051 |
| Number of pages | 6 |
| Journal | Cancer Research |
| Volume | 45 |
| Issue number | 3 |
| State | Published - Jan 1 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Flow cytometric studies on modulation of cellular Adriamycin retention by phenothiazines. / Krishan, A.; Sauerteig, A.; Wellham, L. L.
In: Cancer Research, Vol. 45, No. 3, 01.01.1985, p. 1046-1051.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Flow cytometric studies on modulation of cellular Adriamycin retention by phenothiazines
AU - Krishan, A.
AU - Sauerteig, A.
AU - Wellham, L. L.
PY - 1985/1/1
Y1 - 1985/1/1
N2 - Phenothiazines (chlorpromazine and trifluoperazine) enhance the cellular retention and cytotoxicity of Adriamycin in P388/S and P388/R cells. Effects on the resistant cells are more pronounced than those on the sensitive cels. Multiparametric flow-cytometric determination of cellular Adriamycin fluorescence shows that the phenothiazine effects are not uniform in a cell population, and cells in later part of the cell cycle traverse (S and G2/M), mitogen-stimulated lymphocytes (as compared to nonstimulated lymphocytes), and ascites (as compared to splenocytes) have greater sensitivity to phenothiazine effects on Adriamycin retention.
AB - Phenothiazines (chlorpromazine and trifluoperazine) enhance the cellular retention and cytotoxicity of Adriamycin in P388/S and P388/R cells. Effects on the resistant cells are more pronounced than those on the sensitive cels. Multiparametric flow-cytometric determination of cellular Adriamycin fluorescence shows that the phenothiazine effects are not uniform in a cell population, and cells in later part of the cell cycle traverse (S and G2/M), mitogen-stimulated lymphocytes (as compared to nonstimulated lymphocytes), and ascites (as compared to splenocytes) have greater sensitivity to phenothiazine effects on Adriamycin retention.
UR - http://www.scopus.com/inward/record.url?scp=0021953802&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021953802&partnerID=8YFLogxK
M3 - Article
C2 - 4038625
AN - SCOPUS:0021953802
VL - 45
SP - 1046
EP - 1051
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0099-7013
IS - 3
ER -