Flow cytometric studies on modulation of cellular Adriamycin retention by phenothiazines

A. Krishan, A. Sauerteig, L. L. Wellham

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Phenothiazines (chlorpromazine and trifluoperazine) enhance the cellular retention and cytotoxicity of Adriamycin in P388/S and P388/R cells. Effects on the resistant cells are more pronounced than those on the sensitive cels. Multiparametric flow-cytometric determination of cellular Adriamycin fluorescence shows that the phenothiazine effects are not uniform in a cell population, and cells in later part of the cell cycle traverse (S and G2/M), mitogen-stimulated lymphocytes (as compared to nonstimulated lymphocytes), and ascites (as compared to splenocytes) have greater sensitivity to phenothiazine effects on Adriamycin retention.

Original languageEnglish
Pages (from-to)1046-1051
Number of pages6
JournalCancer Research
Volume45
Issue number3
StatePublished - Jan 1 1985
Externally publishedYes

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Phenothiazines
Doxorubicin
Lymphocytes
Trifluoperazine
Chlorpromazine
Mitogens
Ascites
Cell Cycle
Fluorescence
Population
phenothiazine

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Krishan, A., Sauerteig, A., & Wellham, L. L. (1985). Flow cytometric studies on modulation of cellular Adriamycin retention by phenothiazines. Cancer Research, 45(3), 1046-1051.

Flow cytometric studies on modulation of cellular Adriamycin retention by phenothiazines. / Krishan, A.; Sauerteig, A.; Wellham, L. L.

In: Cancer Research, Vol. 45, No. 3, 01.01.1985, p. 1046-1051.

Research output: Contribution to journalArticle

Krishan, A, Sauerteig, A & Wellham, LL 1985, 'Flow cytometric studies on modulation of cellular Adriamycin retention by phenothiazines', Cancer Research, vol. 45, no. 3, pp. 1046-1051.
Krishan, A. ; Sauerteig, A. ; Wellham, L. L. / Flow cytometric studies on modulation of cellular Adriamycin retention by phenothiazines. In: Cancer Research. 1985 ; Vol. 45, No. 3. pp. 1046-1051.
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