Flow Cytometric Studies on Modulation of Cellular Adriamycin Retention by Phenothiazines

Awtar Krishan, Antonieta Sauerteig, Larry L. Wellham

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Phenothiazines (chlorpromazine and trifluoperazine) enhance the cellular retention and cytotoxicity of Adriamycin in P388/S and P388/R cells. Effects on the resistant cells are more pronounced than those on the sensitive cels. Multiparametric flow-cytometric determination of cellular Adriamycin fluorescence shows that the phenothiazine effects are not uniform in a cell population, and cells in later part of the cell cycle traverse (S and G2/M), mitogen-stimulated lymphocytes (as compared to nonstimulated lymphocytes), and ascites (as compared to splenocytes) have greater sensitivity to phenothiazine effects on Adriamycin retention.

Original languageEnglish (US)
Pages (from-to)1046-1051
Number of pages6
JournalCancer Research
Volume45
Issue number3
StatePublished - Mar 1 1985

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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