Flow cytometric monitoring of R 3327 rat prostate carcinoma

J. M. Collins, C. B. Bagwell, Norman L Block, A. J. Claflin, G. L. Irvin, Alan Pollack, B. Stover

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The R 3327 G tumor responds to estrogen in early stages, but relapses when estrogen therapy is continued beyond 50 days postimplantation. Measurement of DNA content per cell by flow cytometric analysis revealed two populations of cells in the tumors with ploidies of 2 c and 3.2 c. The proportion of aneuploid cells (3.2 c), determined from the flow cytometric DNA distributions, correlated well with tumor weight and age in control and estrogen treated animals. The simple parameter of per cent aneuploid cells thus adequately reflected the responsive and unresponsive states of tumors under hormonal therapy.

Original languageEnglish
Pages (from-to)8-13
Number of pages6
JournalInvestigative Urology
Volume19
Issue number1
StatePublished - Oct 9 1981
Externally publishedYes

Fingerprint

Prostate
Estrogens
Aneuploidy
Carcinoma
Neoplasms
Ploidies
DNA
Tumor Burden
Recurrence
Therapeutics
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Collins, J. M., Bagwell, C. B., Block, N. L., Claflin, A. J., Irvin, G. L., Pollack, A., & Stover, B. (1981). Flow cytometric monitoring of R 3327 rat prostate carcinoma. Investigative Urology, 19(1), 8-13.

Flow cytometric monitoring of R 3327 rat prostate carcinoma. / Collins, J. M.; Bagwell, C. B.; Block, Norman L; Claflin, A. J.; Irvin, G. L.; Pollack, Alan; Stover, B.

In: Investigative Urology, Vol. 19, No. 1, 09.10.1981, p. 8-13.

Research output: Contribution to journalArticle

Collins, JM, Bagwell, CB, Block, NL, Claflin, AJ, Irvin, GL, Pollack, A & Stover, B 1981, 'Flow cytometric monitoring of R 3327 rat prostate carcinoma', Investigative Urology, vol. 19, no. 1, pp. 8-13.
Collins JM, Bagwell CB, Block NL, Claflin AJ, Irvin GL, Pollack A et al. Flow cytometric monitoring of R 3327 rat prostate carcinoma. Investigative Urology. 1981 Oct 9;19(1):8-13.
Collins, J. M. ; Bagwell, C. B. ; Block, Norman L ; Claflin, A. J. ; Irvin, G. L. ; Pollack, Alan ; Stover, B. / Flow cytometric monitoring of R 3327 rat prostate carcinoma. In: Investigative Urology. 1981 ; Vol. 19, No. 1. pp. 8-13.
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