Flavonoids protect against intercellular adhesion molecule-1 induction by benzo[a]pyrene

Elizabeth Oesterling Owens, Michal Toborek, Bernhard Hennig

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Dietary changes are an attractive means of protecting against environmental chemical exposure. Exposure to benzo[a]pyrene (B[a]P) is a risk factor for cardiovascular disease events. It has recently been shown that B[a]P can increase intercellular adhesion molecule-1 (ICAM-1) in endothelial cells, a possible means of promoting cardiovascular disease. This study investigated the ability of flavonoids to protect against B[a]P-induced ICAM-1. It was shown that only flavonoids that contain a 4' B-ring hydroxyl substitution and a 2-3 C-ring double bond were protective. These data suggest that selected bioactive compounds can decrease proinflammatory properties of environmental chemicals such as B[a]P.

Original languageEnglish (US)
Pages (from-to)4-7
Number of pages4
JournalBulletin of Environmental Contamination and Toxicology
Volume83
Issue number1
DOIs
StatePublished - Jul 1 2009

Keywords

  • Atherosclerosis
  • Benzo[a]pyrene
  • Flavonoids
  • Intercellular adhesion molecule-1

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Pollution
  • Toxicology

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