Dietary changes are an attractive means of protecting against environmental chemical exposure. Exposure to benzo[a]pyrene (B[a]P) is a risk factor for cardiovascular disease events. It has recently been shown that B[a]P can increase intercellular adhesion molecule-1 (ICAM-1) in endothelial cells, a possible means of promoting cardiovascular disease. This study investigated the ability of flavonoids to protect against B[a]P-induced ICAM-1. It was shown that only flavonoids that contain a 4' B-ring hydroxyl substitution and a 2-3 C-ring double bond were protective. These data suggest that selected bioactive compounds can decrease proinflammatory properties of environmental chemicals such as B[a]P.
|Original language||English (US)|
|Number of pages||4|
|Journal||Bulletin of Environmental Contamination and Toxicology|
|State||Published - Jul 2009|
- Intercellular adhesion molecule-1
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis