TY - JOUR
T1 - First-time use of bevacizumab for aggressive, metastatic hepatocellular carcinoma in an HIV/hepatitis B virus coinfected patient
T2 - A case report
AU - Baraboutis, Ioannis G.
AU - Papastamopoulos, Vassilios
AU - Charitsis, Georgios
AU - Lekakis, Lazaros J.
AU - Vaslamatzis, Michael M.
AU - Skoutelis, Athanasios T.
PY - 2008/5/1
Y1 - 2008/5/1
N2 - We present a case of an HIV-1 infected patient with history of chronic hepatitis B and chronic alcohol use without cirrhosis, who presented with aggressive hepatocellular carcinoma with multiple metastases. Systemic chemotherapy combined with use of bevacizumab (anti-vascular endothelium growth factor monoclonal antibody) was without effect and the patient succumbed to his disease within few weeks. To our knowledge, this is the first report in the English literature of bevacizumab use for metastatic hepatocellular carcinoma in HIV-infected patients.
AB - We present a case of an HIV-1 infected patient with history of chronic hepatitis B and chronic alcohol use without cirrhosis, who presented with aggressive hepatocellular carcinoma with multiple metastases. Systemic chemotherapy combined with use of bevacizumab (anti-vascular endothelium growth factor monoclonal antibody) was without effect and the patient succumbed to his disease within few weeks. To our knowledge, this is the first report in the English literature of bevacizumab use for metastatic hepatocellular carcinoma in HIV-infected patients.
KW - Anti-vascular endothelium growth factor
KW - Bevacizumab
KW - HIV/hepatitis B virus coinfection
KW - Metastatic hepatocellular carcinoma
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U2 - 10.1097/MEG.0b013e3282f16411
DO - 10.1097/MEG.0b013e3282f16411
M3 - Article
C2 - 18403951
AN - SCOPUS:42149167957
VL - 20
SP - 472
EP - 473
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
SN - 0954-691X
IS - 5
ER -