Fingerprinting acute leukemia: DNA methylation profiling of B-acute lymphoblastic leukemia

Luisa Cimmino, Iannis Aifantis

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

In this issue of Cancer Discovery, Geng and colleagues report on their use of a combination of promoter cytosine methylation profiling with gene expression and ChIP sequencing to elucidate molecular signatures of adult B-acute lymphoblastic leukemia patient samples with BCR-ABL1, E2A-PBX1, and MLL rearrangements. The unique epigenetic and gene expression signatures of these clinically unfavorable B-ALL subtypes identify novel biomarkers and provide a strong rationale for repurposing existing therapies to treat these molecularly distinct diseases.

Original languageEnglish (US)
Pages (from-to)976-978
Number of pages3
JournalCancer discovery
Volume2
Issue number11
DOIs
StatePublished - Nov 2012
Externally publishedYes

ASJC Scopus subject areas

  • Oncology

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