Fine tuning a well-oiled machine: Influence of NK1.1 and NKG2D on NKT cell development and function

Sunil Joshi, Mark L. Lang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Natural killer T cells (NKT) represent a group of CD1d-restricted T-lineage cells that provide a functional interface between innate and adaptive immune responses in infectious disease, cancer, allergy and autoimmunity. There have been remarkable advances in understanding the molecular events that underpin NKT development in the thymus and in the complex array of functions in the periphery. Most functional studies have focused on activation of T cell antigen receptors expressed by NKT cells and their responses to CD1d presentation of glycolipid and related antigens. Receiving less attention has been several molecules that are hallmarks of Natural Killer (NK) cells, but nonetheless expressed by NKT cells. These include several activating and inhibitory receptors that may fine-tune NKT development and survival, as well as activation via antigen receptors. Herein, we review the possible roles of the NK1.1 and NKG2D receptors in regulating development and function of NKT cells in health and disease. We suggest that pharmacological alteration of NKT activity should consider the potential complexities commensurate with NK1.1 and NKG2D expression.

Original languageEnglish (US)
Pages (from-to)260-266
Number of pages7
JournalInternational Immunopharmacology
Volume17
Issue number2
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

Natural Killer T-Cells
NK Cell Lectin-Like Receptor Subfamily K
Antigen Receptors
Glycolipids
Adaptive Immunity
T-Cell Antigen Receptor
Autoimmunity
Innate Immunity
Natural Killer Cells
Thymus Gland
Communicable Diseases
Cell Survival
Hypersensitivity
Pharmacology
Antigens
Health

Keywords

  • Adaptive immunity
  • NK1.1
  • NKG2D
  • NKT cells
  • Pathogenesis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Fine tuning a well-oiled machine : Influence of NK1.1 and NKG2D on NKT cell development and function. / Joshi, Sunil; Lang, Mark L.

In: International Immunopharmacology, Vol. 17, No. 2, 01.01.2013, p. 260-266.

Research output: Contribution to journalArticle

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