TY - JOUR
T1 - Fine structure of the kinetochores in vinblastine sulfate-treated cells
AU - Krishan, Awtar
N1 - Funding Information:
These studies were supported in part by research grants C-6516 from the National Cancer Institute, and FR-05526 from the Division of Research Facilities and Resources, National Institute of Health; the legacy of Loula D. Lasker; the Albert and Mary Lasker Foundation, New York; and the Alvin T. and Viola D. Fuller Cancer Research Unit Grant, American Cancer Society (Massachusetts Division), Inc.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1968/4
Y1 - 1968/4
N2 - Cells arrested in mitosis by vinblastine sulfate (Velban, Lilly) have prominent kinetochores or centromeres showing details of fine structure usually not seen in untreated dividing cells. In many of these cells 250-300 Å wide bands of electron-dense material surrounded by and separated from the chromatin by fine fibrous or amorphous, light-stained material are seen in the kinetochore region. In some sections these dense bands are as long as 4500, and often more than one band can be seen in the kinetochore region. In suitable sections, the median dense band is seen to consist of two apparent subunits which are 100 Å wide and separated by a 50-60 Å space.
AB - Cells arrested in mitosis by vinblastine sulfate (Velban, Lilly) have prominent kinetochores or centromeres showing details of fine structure usually not seen in untreated dividing cells. In many of these cells 250-300 Å wide bands of electron-dense material surrounded by and separated from the chromatin by fine fibrous or amorphous, light-stained material are seen in the kinetochore region. In some sections these dense bands are as long as 4500, and often more than one band can be seen in the kinetochore region. In suitable sections, the median dense band is seen to consist of two apparent subunits which are 100 Å wide and separated by a 50-60 Å space.
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U2 - 10.1016/S0022-5320(68)80037-1
DO - 10.1016/S0022-5320(68)80037-1
M3 - Article
C2 - 5670835
AN - SCOPUS:0014269346
VL - 23
SP - 134
EP - 143
JO - Journal of Structural Biology
JF - Journal of Structural Biology
SN - 1047-8477
IS - 1-2
ER -