Abstract
Objective: To report on multinucleated giant cells (MNGCs) in salivary fine needle aspiration (FNA). Study Design: The cytologic reports of salivary gland region FNA during a 10-year period was searched using the keyword giant cell in the final diagnosis or microscopic description. Cases with foreign body-type giant cells secondary to previous biopsy or FNA were excluded. Histologic correlations and immunohistochemical staining for CD68, CK, FMA, S100, HMB45 and CD1a were performed on selected cases. Results: Twenty-six aspiration smears containing MNGCs were identified from 1,040 salivary gland FNAs (2.5%). MNGCs were seen in some reactive or inflammatory conditions, benign neoplasms and malignant neoplasms. By type of MNGC, the salivary lesions were categorized in 3 groups: those with foreign body type, osteoclast type and tumor giant cells. Conclusion: MNGCs can be seen in a wide spectrum of salivary gland lesions ranging from reactive to benign and malignant. They are of nonepithelial origin or can be of true neoplastic nature in metastatic lesions.
| Original language | English |
|---|---|
| Pages (from-to) | 671-680 |
| Number of pages | 10 |
| Journal | Acta Cytologica |
| Volume | 52 |
| Issue number | 6 |
| State | Published - Jan 1 2008 |
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Keywords
- Aspiration cytology, fine-needle
- Giant cell tumor
- Multinucleated giant cells
- Salivary gland tumor
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
Cite this
Fine needle aspiration of salivary gland lesions with multinucleated giant cells. / Daneshbod, Yahya; Khademi, Bijan; Kadivar, Maryam; Ganjei-Azar, Parvin.
In: Acta Cytologica, Vol. 52, No. 6, 01.01.2008, p. 671-680.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fine needle aspiration of salivary gland lesions with multinucleated giant cells
AU - Daneshbod, Yahya
AU - Khademi, Bijan
AU - Kadivar, Maryam
AU - Ganjei-Azar, Parvin
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Objective: To report on multinucleated giant cells (MNGCs) in salivary fine needle aspiration (FNA). Study Design: The cytologic reports of salivary gland region FNA during a 10-year period was searched using the keyword giant cell in the final diagnosis or microscopic description. Cases with foreign body-type giant cells secondary to previous biopsy or FNA were excluded. Histologic correlations and immunohistochemical staining for CD68, CK, FMA, S100, HMB45 and CD1a were performed on selected cases. Results: Twenty-six aspiration smears containing MNGCs were identified from 1,040 salivary gland FNAs (2.5%). MNGCs were seen in some reactive or inflammatory conditions, benign neoplasms and malignant neoplasms. By type of MNGC, the salivary lesions were categorized in 3 groups: those with foreign body type, osteoclast type and tumor giant cells. Conclusion: MNGCs can be seen in a wide spectrum of salivary gland lesions ranging from reactive to benign and malignant. They are of nonepithelial origin or can be of true neoplastic nature in metastatic lesions.
AB - Objective: To report on multinucleated giant cells (MNGCs) in salivary fine needle aspiration (FNA). Study Design: The cytologic reports of salivary gland region FNA during a 10-year period was searched using the keyword giant cell in the final diagnosis or microscopic description. Cases with foreign body-type giant cells secondary to previous biopsy or FNA were excluded. Histologic correlations and immunohistochemical staining for CD68, CK, FMA, S100, HMB45 and CD1a were performed on selected cases. Results: Twenty-six aspiration smears containing MNGCs were identified from 1,040 salivary gland FNAs (2.5%). MNGCs were seen in some reactive or inflammatory conditions, benign neoplasms and malignant neoplasms. By type of MNGC, the salivary lesions were categorized in 3 groups: those with foreign body type, osteoclast type and tumor giant cells. Conclusion: MNGCs can be seen in a wide spectrum of salivary gland lesions ranging from reactive to benign and malignant. They are of nonepithelial origin or can be of true neoplastic nature in metastatic lesions.
KW - Aspiration cytology, fine-needle
KW - Giant cell tumor
KW - Multinucleated giant cells
KW - Salivary gland tumor
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UR - http://www.scopus.com/inward/citedby.url?scp=56749148417&partnerID=8YFLogxK
M3 - Article
C2 - 19068670
AN - SCOPUS:56749148417
VL - 52
SP - 671
EP - 680
JO - Acta Cytologica
JF - Acta Cytologica
SN - 0001-5547
IS - 6
ER -