Fine-needle aspiration (FNA) and pleural fluid cytology diagnosis of benign metastasizing pleomorphic adenoma of the parotid gland in the lung

A case report and review of literature

Zhang Yaxia, Carmen Gomez-Fernandez, Merce Jorda, Parvin Ganjei-Azar

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Lesions that contain abundant benign myoepithelial cells, including pleomorphic adenomas of salivary gland origin, may present a diagnostic challenge in fine-needle aspiration (FNA) specimens. Benign metastasizing pleomorphic adenoma is a rare neoplasm, in which the benign appearing pleomorphic adenoma, without any histological evidence of malignancy, metastasizes to distant sites including lung. In the absence of clinical history of a pre-existing myoepithelial neoplasm, the presence of myoepithelial cells in the lung or any other organs besides salivary glands may create diagnostic difficulty. Here we present the cytologic findings of such a metastatic tumor found in the lung FNA and pleural fluid specimens from a 64-year-old woman, with a history of local recurrent salivary gland pleomorphic adenomas, who presented with multiple bilateral pulmonary nodules and pleural effusion. The diagnosis of benign metastasizing pleomorphic adenoma was made based on clinical information and cytomorphology, and confirmed by immunocytochemistry.

Original languageEnglish
Pages (from-to)828-831
Number of pages4
JournalDiagnostic Cytopathology
Volume37
Issue number11
DOIs
StatePublished - Nov 1 2009

Fingerprint

Pleomorphic Adenoma
Parotid Gland
Fine Needle Biopsy
Cell Biology
Lung
Neoplasms
Multiple Pulmonary Nodules
Pleural Effusion
Salivary Glands
Immunohistochemistry
Pleomorphic Salivary Gland Adenoma

Keywords

  • Benign metastasizing pleomorphic adenoma
  • Cytology
  • Fine-needle aspiration
  • Lung
  • Pleural fluid cytology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

@article{1072a6f4fc6d4578be482d48b2a2af9b,
title = "Fine-needle aspiration (FNA) and pleural fluid cytology diagnosis of benign metastasizing pleomorphic adenoma of the parotid gland in the lung: A case report and review of literature",
abstract = "Lesions that contain abundant benign myoepithelial cells, including pleomorphic adenomas of salivary gland origin, may present a diagnostic challenge in fine-needle aspiration (FNA) specimens. Benign metastasizing pleomorphic adenoma is a rare neoplasm, in which the benign appearing pleomorphic adenoma, without any histological evidence of malignancy, metastasizes to distant sites including lung. In the absence of clinical history of a pre-existing myoepithelial neoplasm, the presence of myoepithelial cells in the lung or any other organs besides salivary glands may create diagnostic difficulty. Here we present the cytologic findings of such a metastatic tumor found in the lung FNA and pleural fluid specimens from a 64-year-old woman, with a history of local recurrent salivary gland pleomorphic adenomas, who presented with multiple bilateral pulmonary nodules and pleural effusion. The diagnosis of benign metastasizing pleomorphic adenoma was made based on clinical information and cytomorphology, and confirmed by immunocytochemistry.",
keywords = "Benign metastasizing pleomorphic adenoma, Cytology, Fine-needle aspiration, Lung, Pleural fluid cytology",
author = "Zhang Yaxia and Carmen Gomez-Fernandez and Merce Jorda and Parvin Ganjei-Azar",
year = "2009",
month = "11",
day = "1",
doi = "10.1002/dc.21123",
language = "English",
volume = "37",
pages = "828--831",
journal = "Diagnostic Cytopathology",
issn = "8755-1039",
publisher = "Wiley-Liss Inc.",
number = "11",

}

TY - JOUR

T1 - Fine-needle aspiration (FNA) and pleural fluid cytology diagnosis of benign metastasizing pleomorphic adenoma of the parotid gland in the lung

T2 - A case report and review of literature

AU - Yaxia, Zhang

AU - Gomez-Fernandez, Carmen

AU - Jorda, Merce

AU - Ganjei-Azar, Parvin

PY - 2009/11/1

Y1 - 2009/11/1

N2 - Lesions that contain abundant benign myoepithelial cells, including pleomorphic adenomas of salivary gland origin, may present a diagnostic challenge in fine-needle aspiration (FNA) specimens. Benign metastasizing pleomorphic adenoma is a rare neoplasm, in which the benign appearing pleomorphic adenoma, without any histological evidence of malignancy, metastasizes to distant sites including lung. In the absence of clinical history of a pre-existing myoepithelial neoplasm, the presence of myoepithelial cells in the lung or any other organs besides salivary glands may create diagnostic difficulty. Here we present the cytologic findings of such a metastatic tumor found in the lung FNA and pleural fluid specimens from a 64-year-old woman, with a history of local recurrent salivary gland pleomorphic adenomas, who presented with multiple bilateral pulmonary nodules and pleural effusion. The diagnosis of benign metastasizing pleomorphic adenoma was made based on clinical information and cytomorphology, and confirmed by immunocytochemistry.

AB - Lesions that contain abundant benign myoepithelial cells, including pleomorphic adenomas of salivary gland origin, may present a diagnostic challenge in fine-needle aspiration (FNA) specimens. Benign metastasizing pleomorphic adenoma is a rare neoplasm, in which the benign appearing pleomorphic adenoma, without any histological evidence of malignancy, metastasizes to distant sites including lung. In the absence of clinical history of a pre-existing myoepithelial neoplasm, the presence of myoepithelial cells in the lung or any other organs besides salivary glands may create diagnostic difficulty. Here we present the cytologic findings of such a metastatic tumor found in the lung FNA and pleural fluid specimens from a 64-year-old woman, with a history of local recurrent salivary gland pleomorphic adenomas, who presented with multiple bilateral pulmonary nodules and pleural effusion. The diagnosis of benign metastasizing pleomorphic adenoma was made based on clinical information and cytomorphology, and confirmed by immunocytochemistry.

KW - Benign metastasizing pleomorphic adenoma

KW - Cytology

KW - Fine-needle aspiration

KW - Lung

KW - Pleural fluid cytology

UR - http://www.scopus.com/inward/record.url?scp=70350345858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350345858&partnerID=8YFLogxK

U2 - 10.1002/dc.21123

DO - 10.1002/dc.21123

M3 - Article

VL - 37

SP - 828

EP - 831

JO - Diagnostic Cytopathology

JF - Diagnostic Cytopathology

SN - 8755-1039

IS - 11

ER -