Fine needle aspiration biopsy with adjunct immunohistochemistry in intraocular tumor management

Beverly E. Faulkner-Jones, William J. Foster, J. William Harbour, Morton E. Smith, Rosa M. Dávila

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Objective: To assess the effectiveness of fine needle aspiration biopsy (FNAB), with and without immunohistochemistry (IHC), in the management of solid intraocular tumors. Study Design: Thirty-three consecutive adults undergoing FNAB of suspected intraocular tumors were studied. Clinical, cytologie and histologic diagnoses were correlated. The positive predictive value, sensitivity and specificity of FNAB for detecting malignancy, the effeet of IHC on the final cytologic diagnosis and the number of patients in whom clinical management was altered as a result of cytologic evaluation were determined. Results: The positive predictive value was 96% with and 93% without adjunct IHC. The sensitivity and specificity of FNAB for detecting malignancy were 96% and 83%, respectively, with IHC. Without IHC, the sensitivity was unaltered, but the specificity was 67%. IHC confirmed the morphologic diagnosis in 75% of cases, made a diagnosis in 12.5% and changed a malignant diagnosis from carcinoma to melanoma in 6% of cases. The planned management was changed by the FNAB findings in 24% of patients. In 3 patients (9%), IHC was essential for diagnosis and management. No patients exhibited local tumor dissemination or recurrence associated with the biopsy. Conclusion: FNAB is a safe, sensitive and specific method of establishing a tissue diagnosis in a subset of patients with solid intraocular tumors. The routine use of immunohistochemical staining increases the diagnostic utility of the technique and may change clinical management.

Original languageEnglish
Pages (from-to)297-308
Number of pages12
JournalActa Cytologica
Volume49
Issue number3
StatePublished - Jan 1 2005
Externally publishedYes

Fingerprint

Fine Needle Biopsy
Immunohistochemistry
Neoplasms
Sensitivity and Specificity
Melanoma
Staining and Labeling
Carcinoma
Biopsy
Recurrence

Keywords

  • Aspiration biopsy, fine-needle
  • Eye neoplasms
  • Immunohistochemistry

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology
  • Histology

Cite this

Faulkner-Jones, B. E., Foster, W. J., William Harbour, J., Smith, M. E., & Dávila, R. M. (2005). Fine needle aspiration biopsy with adjunct immunohistochemistry in intraocular tumor management. Acta Cytologica, 49(3), 297-308.

Fine needle aspiration biopsy with adjunct immunohistochemistry in intraocular tumor management. / Faulkner-Jones, Beverly E.; Foster, William J.; William Harbour, J.; Smith, Morton E.; Dávila, Rosa M.

In: Acta Cytologica, Vol. 49, No. 3, 01.01.2005, p. 297-308.

Research output: Contribution to journalArticle

Faulkner-Jones, BE, Foster, WJ, William Harbour, J, Smith, ME & Dávila, RM 2005, 'Fine needle aspiration biopsy with adjunct immunohistochemistry in intraocular tumor management', Acta Cytologica, vol. 49, no. 3, pp. 297-308.
Faulkner-Jones, Beverly E. ; Foster, William J. ; William Harbour, J. ; Smith, Morton E. ; Dávila, Rosa M. / Fine needle aspiration biopsy with adjunct immunohistochemistry in intraocular tumor management. In: Acta Cytologica. 2005 ; Vol. 49, No. 3. pp. 297-308.
@article{4eede03677694c04bb9fb259f3fb41fa,
title = "Fine needle aspiration biopsy with adjunct immunohistochemistry in intraocular tumor management",
abstract = "Objective: To assess the effectiveness of fine needle aspiration biopsy (FNAB), with and without immunohistochemistry (IHC), in the management of solid intraocular tumors. Study Design: Thirty-three consecutive adults undergoing FNAB of suspected intraocular tumors were studied. Clinical, cytologie and histologic diagnoses were correlated. The positive predictive value, sensitivity and specificity of FNAB for detecting malignancy, the effeet of IHC on the final cytologic diagnosis and the number of patients in whom clinical management was altered as a result of cytologic evaluation were determined. Results: The positive predictive value was 96{\%} with and 93{\%} without adjunct IHC. The sensitivity and specificity of FNAB for detecting malignancy were 96{\%} and 83{\%}, respectively, with IHC. Without IHC, the sensitivity was unaltered, but the specificity was 67{\%}. IHC confirmed the morphologic diagnosis in 75{\%} of cases, made a diagnosis in 12.5{\%} and changed a malignant diagnosis from carcinoma to melanoma in 6{\%} of cases. The planned management was changed by the FNAB findings in 24{\%} of patients. In 3 patients (9{\%}), IHC was essential for diagnosis and management. No patients exhibited local tumor dissemination or recurrence associated with the biopsy. Conclusion: FNAB is a safe, sensitive and specific method of establishing a tissue diagnosis in a subset of patients with solid intraocular tumors. The routine use of immunohistochemical staining increases the diagnostic utility of the technique and may change clinical management.",
keywords = "Aspiration biopsy, fine-needle, Eye neoplasms, Immunohistochemistry",
author = "Faulkner-Jones, {Beverly E.} and Foster, {William J.} and {William Harbour}, J. and Smith, {Morton E.} and D{\'a}vila, {Rosa M.}",
year = "2005",
month = "1",
day = "1",
language = "English",
volume = "49",
pages = "297--308",
journal = "Acta Cytologica",
issn = "0001-5547",
publisher = "Science Printers and Publishers Inc.",
number = "3",

}

TY - JOUR

T1 - Fine needle aspiration biopsy with adjunct immunohistochemistry in intraocular tumor management

AU - Faulkner-Jones, Beverly E.

AU - Foster, William J.

AU - William Harbour, J.

AU - Smith, Morton E.

AU - Dávila, Rosa M.

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Objective: To assess the effectiveness of fine needle aspiration biopsy (FNAB), with and without immunohistochemistry (IHC), in the management of solid intraocular tumors. Study Design: Thirty-three consecutive adults undergoing FNAB of suspected intraocular tumors were studied. Clinical, cytologie and histologic diagnoses were correlated. The positive predictive value, sensitivity and specificity of FNAB for detecting malignancy, the effeet of IHC on the final cytologic diagnosis and the number of patients in whom clinical management was altered as a result of cytologic evaluation were determined. Results: The positive predictive value was 96% with and 93% without adjunct IHC. The sensitivity and specificity of FNAB for detecting malignancy were 96% and 83%, respectively, with IHC. Without IHC, the sensitivity was unaltered, but the specificity was 67%. IHC confirmed the morphologic diagnosis in 75% of cases, made a diagnosis in 12.5% and changed a malignant diagnosis from carcinoma to melanoma in 6% of cases. The planned management was changed by the FNAB findings in 24% of patients. In 3 patients (9%), IHC was essential for diagnosis and management. No patients exhibited local tumor dissemination or recurrence associated with the biopsy. Conclusion: FNAB is a safe, sensitive and specific method of establishing a tissue diagnosis in a subset of patients with solid intraocular tumors. The routine use of immunohistochemical staining increases the diagnostic utility of the technique and may change clinical management.

AB - Objective: To assess the effectiveness of fine needle aspiration biopsy (FNAB), with and without immunohistochemistry (IHC), in the management of solid intraocular tumors. Study Design: Thirty-three consecutive adults undergoing FNAB of suspected intraocular tumors were studied. Clinical, cytologie and histologic diagnoses were correlated. The positive predictive value, sensitivity and specificity of FNAB for detecting malignancy, the effeet of IHC on the final cytologic diagnosis and the number of patients in whom clinical management was altered as a result of cytologic evaluation were determined. Results: The positive predictive value was 96% with and 93% without adjunct IHC. The sensitivity and specificity of FNAB for detecting malignancy were 96% and 83%, respectively, with IHC. Without IHC, the sensitivity was unaltered, but the specificity was 67%. IHC confirmed the morphologic diagnosis in 75% of cases, made a diagnosis in 12.5% and changed a malignant diagnosis from carcinoma to melanoma in 6% of cases. The planned management was changed by the FNAB findings in 24% of patients. In 3 patients (9%), IHC was essential for diagnosis and management. No patients exhibited local tumor dissemination or recurrence associated with the biopsy. Conclusion: FNAB is a safe, sensitive and specific method of establishing a tissue diagnosis in a subset of patients with solid intraocular tumors. The routine use of immunohistochemical staining increases the diagnostic utility of the technique and may change clinical management.

KW - Aspiration biopsy, fine-needle

KW - Eye neoplasms

KW - Immunohistochemistry

UR - http://www.scopus.com/inward/record.url?scp=18744411806&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18744411806&partnerID=8YFLogxK

M3 - Article

VL - 49

SP - 297

EP - 308

JO - Acta Cytologica

JF - Acta Cytologica

SN - 0001-5547

IS - 3

ER -