Findings in 12-core transrectal ultrasound-guided prostate needle biopsy that predict more advanced cancer at prostatectomy: Analysis of 388 biopsy-prostatectomy pairs

Oleksandr N. Kryvenko, Mireya Diaz, Frederick A. Meier, Maheshwari Ramineni, Mani Menon, Nilesh S. Gupta

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

We analyzed 5 features on 12-core transrectal ultrasound-guided prostate needle biopsy (TRUS) to predict the extent of cancer at radical prostatectomy (RP). In 388 TRUS-RP pairs, number of positive cores (NPC), percentage of each core involved (%PC), perineural invasion (PNI), Gleason score (GS), distribution of positive cores (DPC), and preoperative prostate-specific antigen (PSA) were correlated with extraprostatic extension (EPE), seminal vesicle invasion (SVI), positive surgical margin (R1), positive lymph nodes (N1), and tumor volume. All features predicted EPE and SVI. NPC, GS, %PC, and PNI strongly predicted R1 status. RP tumor volume was directly proportional to the NPC and %PC. PSA alone and with selected biopsy findings correlated with tumor volume, stage, SVI, and N1 (P < .0001). Contiguous DPC was a significant risk for EPE and SVI (P < .0001) compared with isolated positive cores. Findings at 12-core TRUS along with preoperative PSA reliably predict advanced local disease and have practical value as guides to effective planning for surgical resections.

Original languageEnglish (US)
Pages (from-to)739-746
Number of pages8
JournalAmerican journal of clinical pathology
Volume137
Issue number5
DOIs
StatePublished - May 1 2012
Externally publishedYes

Keywords

  • 12-Core prostate biopsy
  • Advanced stage
  • Prostatectomy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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