Findings in 12-core transrectal ultrasound-guided prostate needle biopsy that predict more advanced cancer at prostatectomy: Analysis of 388 biopsy-prostatectomy pairs

Oleksandr Kryvenko, Mireya Diaz, Frederick A. Meier, Maheshwari Ramineni, Mani Menon, Nilesh S. Gupta

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We analyzed 5 features on 12-core transrectal ultrasound-guided prostate needle biopsy (TRUS) to predict the extent of cancer at radical prostatectomy (RP). In 388 TRUS-RP pairs, number of positive cores (NPC), percentage of each core involved (%PC), perineural invasion (PNI), Gleason score (GS), distribution of positive cores (DPC), and preoperative prostate-specific antigen (PSA) were correlated with extraprostatic extension (EPE), seminal vesicle invasion (SVI), positive surgical margin (R1), positive lymph nodes (N1), and tumor volume. All features predicted EPE and SVI. NPC, GS, %PC, and PNI strongly predicted R1 status. RP tumor volume was directly proportional to the NPC and %PC. PSA alone and with selected biopsy findings correlated with tumor volume, stage, SVI, and N1 (P < .0001). Contiguous DPC was a significant risk for EPE and SVI (P < .0001) compared with isolated positive cores. Findings at 12-core TRUS along with preoperative PSA reliably predict advanced local disease and have practical value as guides to effective planning for surgical resections.

Original languageEnglish (US)
Pages (from-to)739-746
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume137
Issue number5
DOIs
StatePublished - May 2012
Externally publishedYes

Fingerprint

Seminal Vesicles
Needle Biopsy
Prostatectomy
Prostate
Prostate-Specific Antigen
Tumor Burden
Biopsy
Neoplasm Grading
Neoplasms
Lymph Nodes

Keywords

  • 12-Core prostate biopsy
  • Advanced stage
  • Prostatectomy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Findings in 12-core transrectal ultrasound-guided prostate needle biopsy that predict more advanced cancer at prostatectomy : Analysis of 388 biopsy-prostatectomy pairs. / Kryvenko, Oleksandr; Diaz, Mireya; Meier, Frederick A.; Ramineni, Maheshwari; Menon, Mani; Gupta, Nilesh S.

In: American Journal of Clinical Pathology, Vol. 137, No. 5, 05.2012, p. 739-746.

Research output: Contribution to journalArticle

@article{dd98dbbdb61f4ff19e4eaa9963be3ba9,
title = "Findings in 12-core transrectal ultrasound-guided prostate needle biopsy that predict more advanced cancer at prostatectomy: Analysis of 388 biopsy-prostatectomy pairs",
abstract = "We analyzed 5 features on 12-core transrectal ultrasound-guided prostate needle biopsy (TRUS) to predict the extent of cancer at radical prostatectomy (RP). In 388 TRUS-RP pairs, number of positive cores (NPC), percentage of each core involved ({\%}PC), perineural invasion (PNI), Gleason score (GS), distribution of positive cores (DPC), and preoperative prostate-specific antigen (PSA) were correlated with extraprostatic extension (EPE), seminal vesicle invasion (SVI), positive surgical margin (R1), positive lymph nodes (N1), and tumor volume. All features predicted EPE and SVI. NPC, GS, {\%}PC, and PNI strongly predicted R1 status. RP tumor volume was directly proportional to the NPC and {\%}PC. PSA alone and with selected biopsy findings correlated with tumor volume, stage, SVI, and N1 (P < .0001). Contiguous DPC was a significant risk for EPE and SVI (P < .0001) compared with isolated positive cores. Findings at 12-core TRUS along with preoperative PSA reliably predict advanced local disease and have practical value as guides to effective planning for surgical resections.",
keywords = "12-Core prostate biopsy, Advanced stage, Prostatectomy",
author = "Oleksandr Kryvenko and Mireya Diaz and Meier, {Frederick A.} and Maheshwari Ramineni and Mani Menon and Gupta, {Nilesh S.}",
year = "2012",
month = "5",
doi = "10.1309/AJCPWIZ9X2DMBEBM",
language = "English (US)",
volume = "137",
pages = "739--746",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "5",

}

TY - JOUR

T1 - Findings in 12-core transrectal ultrasound-guided prostate needle biopsy that predict more advanced cancer at prostatectomy

T2 - Analysis of 388 biopsy-prostatectomy pairs

AU - Kryvenko, Oleksandr

AU - Diaz, Mireya

AU - Meier, Frederick A.

AU - Ramineni, Maheshwari

AU - Menon, Mani

AU - Gupta, Nilesh S.

PY - 2012/5

Y1 - 2012/5

N2 - We analyzed 5 features on 12-core transrectal ultrasound-guided prostate needle biopsy (TRUS) to predict the extent of cancer at radical prostatectomy (RP). In 388 TRUS-RP pairs, number of positive cores (NPC), percentage of each core involved (%PC), perineural invasion (PNI), Gleason score (GS), distribution of positive cores (DPC), and preoperative prostate-specific antigen (PSA) were correlated with extraprostatic extension (EPE), seminal vesicle invasion (SVI), positive surgical margin (R1), positive lymph nodes (N1), and tumor volume. All features predicted EPE and SVI. NPC, GS, %PC, and PNI strongly predicted R1 status. RP tumor volume was directly proportional to the NPC and %PC. PSA alone and with selected biopsy findings correlated with tumor volume, stage, SVI, and N1 (P < .0001). Contiguous DPC was a significant risk for EPE and SVI (P < .0001) compared with isolated positive cores. Findings at 12-core TRUS along with preoperative PSA reliably predict advanced local disease and have practical value as guides to effective planning for surgical resections.

AB - We analyzed 5 features on 12-core transrectal ultrasound-guided prostate needle biopsy (TRUS) to predict the extent of cancer at radical prostatectomy (RP). In 388 TRUS-RP pairs, number of positive cores (NPC), percentage of each core involved (%PC), perineural invasion (PNI), Gleason score (GS), distribution of positive cores (DPC), and preoperative prostate-specific antigen (PSA) were correlated with extraprostatic extension (EPE), seminal vesicle invasion (SVI), positive surgical margin (R1), positive lymph nodes (N1), and tumor volume. All features predicted EPE and SVI. NPC, GS, %PC, and PNI strongly predicted R1 status. RP tumor volume was directly proportional to the NPC and %PC. PSA alone and with selected biopsy findings correlated with tumor volume, stage, SVI, and N1 (P < .0001). Contiguous DPC was a significant risk for EPE and SVI (P < .0001) compared with isolated positive cores. Findings at 12-core TRUS along with preoperative PSA reliably predict advanced local disease and have practical value as guides to effective planning for surgical resections.

KW - 12-Core prostate biopsy

KW - Advanced stage

KW - Prostatectomy

UR - http://www.scopus.com/inward/record.url?scp=84862591764&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862591764&partnerID=8YFLogxK

U2 - 10.1309/AJCPWIZ9X2DMBEBM

DO - 10.1309/AJCPWIZ9X2DMBEBM

M3 - Article

C2 - 22523212

AN - SCOPUS:84862591764

VL - 137

SP - 739

EP - 746

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 5

ER -