Finding specific genes that cause autism: A combination of approaches will be needed to maximize power

Susan E. Folstein, Erica Bisson, Susan L. Santangelo, Joseph Piven

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

Although autism is clearly inherited, it may be challenging to find the genes involved: The mechanism of inheritance is unknown, families with an autistic child are usually small, parent-child pairs are rare, and a fairly large number of genes may be involved, some or all of which may have a small effect on the phenotype. We discuss several strategies for finding genes, all of which may be used in combination to find the relevant genes.

Original languageEnglish (US)
Pages (from-to)439-445
Number of pages7
JournalJournal of Autism and Developmental Disorders
Volume28
Issue number5
DOIs
StatePublished - Dec 1 1998

Keywords

  • Extremely discordant sibling pairs
  • Genetic linkage
  • Genetic methods
  • Sib-pair analysis

ASJC Scopus subject areas

  • Psychology(all)
  • Developmental and Educational Psychology

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