Finasteride treatment of female pattern hair loss

Matilde Iorizzo, Colombina Vincenzi, Stylianos Voudouris, Bianca Maria Piraccini, Antonella Tosti

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

Objective: To evaluate the efficacy of oral finasteride therapy associated with an oral contraceptive containing drospirenone and ethinyl estradiol in premenopausal women with female pattern hair loss. Setting: Outpatient consultation for hair disorders at the Department of Dermatology, University of Bologna. Patients and Intervention: Thirty-seven women with female pattern hair loss were treated with oral finasteride, 2.5 mg/d, while taking an oral contraceptive containing drospirenone and ethinyl estradiol. Treatment efficacy was evaluated using global photography and the hair density score from videodermoscopy. A self-administered questionnaire was used to assess patient evaluation of treatment effectiveness. Results: At 12-month follow-up, 23 of the 37 patients were rated as improved using global photography (12 were slightly improved, 8 were moderately improved, and 3 were greatly improved). No improvement was recorded in 13 patients. One patient experienced worsening of the condition. There was a statistically significant (P=.002) increase in the hair density score in 12 patients. No adverse reactions to the drug were reported. Conclusions: Sixty-two percent of the patients demonstrated some improvement of their hair loss with the use of finasteride, 2.5 mg/d, while taking the oral contraceptive. It is unclear whether the success was due to a higher dosage of finasteride (2.5 mg instead of 1 mg) or to its association with the oral contraceptive containing drospirenone, which has an antiandrogenic effect. Further studies are necessary to understand which patterns of female pattern hair loss respond better to this treatment.

Original languageEnglish (US)
Pages (from-to)298-302
Number of pages5
JournalArchives of dermatology
Volume142
Issue number3
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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    Iorizzo, M., Vincenzi, C., Voudouris, S., Piraccini, B. M., & Tosti, A. (2006). Finasteride treatment of female pattern hair loss. Archives of dermatology, 142(3), 298-302. https://doi.org/10.1001/archderm.142.3.298