Filgrastim in patients with pneumonia and severe sepsis or septic shock

Richard G. Wunderink, Kenneth V. Leeper, Roland Schein, Steve Nelson, Bennett P. De Boisblanc, Nick Fotheringham, Eileen Logan

Research output: Contribution to journalArticle

64 Scopus citations

Abstract

Study objectives: Evaluate the safety of filgrastim (recombinant methionyl human granulocyte colony-stimulating factor) administration, combined with standard therapy, in patients with pneumonia and either septic shock or severe sepsis who were receiving mechanical ventilation. Design: Multicenter, double-blind, randomized, placebo-controlled study. Setting: ICU, multicenter. Patients: Eighteen patients with pneumonia and hypotension, or in the absence of shock, two or more end-organ dysfunctions, were enrolled and treated. Baseline acute physiology and chronic health evaluation II scores and median age for the filgrastim (n = 12) and placebo (n = 6) groups were 25.0 and 49.5 years and 31.5 and 56.5 years, respectively. Intervention: Filgrastim (300 μg) or placebo was administered IV daily for up to 5 days. Measurements and results: Study end points included safety; biological response, including endogenous cytokine levels, endotoxin levels, and neutrophil counts; and mortality. Cytokine and endotoxin levels were highly variable in both groups. By day 29, 3 of 12 filgrastim-treated patients and 4 of 6 placebo-treated patients had died. There were no differences in types and occunrrences of adverse events, including ARDS, or in outcome between the two groups. Three of four placebo-treated patients had persistent bacterial growth on bronehoscopy repeated after 48 h compared with 2 of 10 filgrastim-treated patients. Conclusion: Filgrastim appeared to be well tolerated in this population of patients with pneumonia and severe sepsis or septic shock. Larger studies to determine the benefit of filgrastim in patients with pneumonia and sepsis or organ dysfunction are warranted.

Original languageEnglish (US)
Pages (from-to)523-529
Number of pages7
JournalCHEST
Volume119
Issue number2
DOIs
StatePublished - Jan 1 2001

Keywords

  • Acute physiology and chronic health evaluation II
  • Clinical trial
  • Filgrastim
  • Pneumonia
  • Sepsis
  • Septic shock

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Wunderink, R. G., Leeper, K. V., Schein, R., Nelson, S., De Boisblanc, B. P., Fotheringham, N., & Logan, E. (2001). Filgrastim in patients with pneumonia and severe sepsis or septic shock. CHEST, 119(2), 523-529. https://doi.org/10.1378/chest.119.2.523