Abstract
The aim of this study was to compare fibulin-5 expression in women with and without anterior vaginal wall prolapse. Vaginal tissues were sampled in a standardized fashion from women with (n = 12) or without (n = 10) anterior vaginal wall prolapse. Quantitative real-time polymerase chain reaction was performed to measure mRNA levels of fibulin-5 (FIB-5). FIB-5 protein expression was assessed by immunohistochemistry. There were no significant differences in demographic data between the two groups. FIB-5 mRNA expression was significantly decreased in women with anterior vaginal wall prolapse compared to women without prolapse [(FIB-5 mean ± SD mRNA expression in relative units) 0.01±0.01 vs. 0.09±0.14, P = 0.04]. Fibulin-5 staining intensity was diminished in women with prolapse compared to women without prolapse [intensity score, median (range), 1 (1 - 2) vs. 3 (2 - 3), P = 0.04]. Fibulin-5 expression is decreased in vaginal biopsies from women with prolapse. Changes in fibulin expression may play a role in the development of pelvic organ prolapse.
| Original language | English |
|---|---|
| Pages (from-to) | 207-211 |
| Number of pages | 5 |
| Journal | International Urogynecology Journal and Pelvic Floor Dysfunction |
| Volume | 20 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 28 2009 |
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Keywords
- Cystocele
- Fibulin
- Prolapse
ASJC Scopus subject areas
- Urology
- Obstetrics and Gynecology
Cite this
Fibulin-5 expression is decreased in women with anterior vaginal wall prolapse. / Takacs, Peter; Nassiri, Mehdi; Viciana, Anita; Candiotti, Keith A; Fornoni, Alessia; Medina, Carlos.
In: International Urogynecology Journal and Pelvic Floor Dysfunction, Vol. 20, No. 2, 28.01.2009, p. 207-211.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fibulin-5 expression is decreased in women with anterior vaginal wall prolapse
AU - Takacs, Peter
AU - Nassiri, Mehdi
AU - Viciana, Anita
AU - Candiotti, Keith A
AU - Fornoni, Alessia
AU - Medina, Carlos
PY - 2009/1/28
Y1 - 2009/1/28
N2 - The aim of this study was to compare fibulin-5 expression in women with and without anterior vaginal wall prolapse. Vaginal tissues were sampled in a standardized fashion from women with (n = 12) or without (n = 10) anterior vaginal wall prolapse. Quantitative real-time polymerase chain reaction was performed to measure mRNA levels of fibulin-5 (FIB-5). FIB-5 protein expression was assessed by immunohistochemistry. There were no significant differences in demographic data between the two groups. FIB-5 mRNA expression was significantly decreased in women with anterior vaginal wall prolapse compared to women without prolapse [(FIB-5 mean ± SD mRNA expression in relative units) 0.01±0.01 vs. 0.09±0.14, P = 0.04]. Fibulin-5 staining intensity was diminished in women with prolapse compared to women without prolapse [intensity score, median (range), 1 (1 - 2) vs. 3 (2 - 3), P = 0.04]. Fibulin-5 expression is decreased in vaginal biopsies from women with prolapse. Changes in fibulin expression may play a role in the development of pelvic organ prolapse.
AB - The aim of this study was to compare fibulin-5 expression in women with and without anterior vaginal wall prolapse. Vaginal tissues were sampled in a standardized fashion from women with (n = 12) or without (n = 10) anterior vaginal wall prolapse. Quantitative real-time polymerase chain reaction was performed to measure mRNA levels of fibulin-5 (FIB-5). FIB-5 protein expression was assessed by immunohistochemistry. There were no significant differences in demographic data between the two groups. FIB-5 mRNA expression was significantly decreased in women with anterior vaginal wall prolapse compared to women without prolapse [(FIB-5 mean ± SD mRNA expression in relative units) 0.01±0.01 vs. 0.09±0.14, P = 0.04]. Fibulin-5 staining intensity was diminished in women with prolapse compared to women without prolapse [intensity score, median (range), 1 (1 - 2) vs. 3 (2 - 3), P = 0.04]. Fibulin-5 expression is decreased in vaginal biopsies from women with prolapse. Changes in fibulin expression may play a role in the development of pelvic organ prolapse.
KW - Cystocele
KW - Fibulin
KW - Prolapse
UR - http://www.scopus.com/inward/record.url?scp=58549120995&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58549120995&partnerID=8YFLogxK
U2 - 10.1007/s00192-008-0757-x
DO - 10.1007/s00192-008-0757-x
M3 - Article
C2 - 18989607
AN - SCOPUS:58549120995
VL - 20
SP - 207
EP - 211
JO - International Urogynecology Journal and Pelvic Floor Dysfunction
JF - International Urogynecology Journal and Pelvic Floor Dysfunction
SN - 0937-3462
IS - 2
ER -