Fibrous papule: An immunohistochemical study with an antibody to S-100 protein

Joan Spiegel, Mehrdad Nadji, Neal S. Penneys

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25 Scopus citations


We studied twenty biopsies taken from fibrous papules which were located in the central part of the face. The lesions, which were characteristic histologically, did not contain S-100 protein within the stellate cells in the papillary dermis, nor was this substance found in mesenchymal cells with some features of nevus cells. In control studies, S-100 protein was found using an unlabeled antibody peroxidase-antiperoxidase technic within nevus cells composing junctional, intradermal, and compound nevi, Spitz nevi, and halo nevi. It therefore seems unlikely that fibrous papule represents a form of degenerated nevus as some investigators have proposed.

Original languageEnglish (US)
Pages (from-to)360-362
Number of pages3
JournalJournal of the American Academy of Dermatology
Issue number3
StatePublished - 1983

ASJC Scopus subject areas

  • Dermatology


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