Fibrous papule: An immunohistochemical study with an antibody to S-100 protein

Joan Spiegel, Mehrdad Nadji, Neal S. Penneys

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

We studied twenty biopsies taken from fibrous papules which were located in the central part of the face. The lesions, which were characteristic histologically, did not contain S-100 protein within the stellate cells in the papillary dermis, nor was this substance found in mesenchymal cells with some features of nevus cells. In control studies, S-100 protein was found using an unlabeled antibody peroxidase-antiperoxidase technic within nevus cells composing junctional, intradermal, and compound nevi, Spitz nevi, and halo nevi. It therefore seems unlikely that fibrous papule represents a form of degenerated nevus as some investigators have proposed.

Original languageEnglish (US)
Pages (from-to)360-362
Number of pages3
JournalJournal of the American Academy of Dermatology
Volume9
Issue number3
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Dermatology

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