Fever: Suppress or let it ride?

Juliet J. Ray, Carl I Schulman

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


While our ability to detect and manage fever has evolved since its conceptualization in the 5th century BC, controversy remains over the best evidence-based practices regarding if and when to treat this physiologic derangement in the critically ill. There are two basic fields of thought: (I) fever should be suppressed because its metabolic costs outweigh its potential physiologic benefit in an already stressed host; vs. (II) fever is a protective adaptive response that should be allowed to run its course under most circumstances. The latter approach, sometime referred to as the "let it ride" philosophy, has been supported by several recent randomized controlled trials like that of Young et al. [2015], which are challenging earlier observational studies and may be pushing the pendulum away from the Pavlovian treatment response.

Original languageEnglish (US)
Pages (from-to)E633-E636
JournalJournal of Thoracic Disease
Issue number12
StatePublished - 2015


  • Acetaminophen
  • Critical care
  • Febrile
  • ICU
  • Infection

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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