Fetoscopic single-layer repair of open spina bifida using a cellulose patch: Preliminary clinical experience

Denise A L Pedreira, Nelci Zanon, Renato A M De Sá, Gregório L. Acacio, Edilson Ogeda, Teresa M L O U Belem, Ramen H. Chmait, Eftichia Kontopoulos, Ruben A. Quintero

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Objective: To report our preliminary clinical experience in the antenatal correction of open spina bifida (OSB) using a fetoscopic approach and a simplified closure technique. Methods: Four fetuses with lumbar-sacral defects were operated in utero from 25 to 27 weeks. Surgeries were performed percutaneously under general anesthesia using three trocars and partial carbon dioxide insufflation. After dissection of the neural placode, the surrounding skin was closed over a cellulose patch using a single continuous stitch. Results: Surgical closure was successful in three of the four cases. All successful cases showed improvement of the hindbrain herniation and no neonatal neurosurgical repair was required in two cases. Delivery occurred between 31 and 33 weeks, and no fetal or neonatal deaths occurred. Ventriculoperitoneal shunting was not needed in two out of the 3 successful cases. Conclusions: Our preliminary experience suggests that definitive fetoscopic repair of OSB is feasible using our innovative surgical technique. A phase I trial for the fetoscopic correction of OSB with this technique is currently being conducted.

Original languageEnglish
Pages (from-to)1613-1619
Number of pages7
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume27
Issue number16
DOIs
StatePublished - Jan 1 2014

Fingerprint

Spina Bifida Cystica
Cellulose
Insufflation
Rhombencephalon
Fetal Death
Surgical Instruments
Carbon Dioxide
General Anesthesia
Dissection
Fetus
Skin

Keywords

  • Cellulose
  • Fetal therapy
  • Fetoscopy
  • Meningomyelocele
  • Myelomeningocele
  • Spina bifida

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Pedreira, D. A. L., Zanon, N., De Sá, R. A. M., Acacio, G. L., Ogeda, E., Belem, T. M. L. O. U., ... Quintero, R. A. (2014). Fetoscopic single-layer repair of open spina bifida using a cellulose patch: Preliminary clinical experience. Journal of Maternal-Fetal and Neonatal Medicine, 27(16), 1613-1619. https://doi.org/10.3109/14767058.2013.871701

Fetoscopic single-layer repair of open spina bifida using a cellulose patch : Preliminary clinical experience. / Pedreira, Denise A L; Zanon, Nelci; De Sá, Renato A M; Acacio, Gregório L.; Ogeda, Edilson; Belem, Teresa M L O U; Chmait, Ramen H.; Kontopoulos, Eftichia; Quintero, Ruben A.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 27, No. 16, 01.01.2014, p. 1613-1619.

Research output: Contribution to journalArticle

Pedreira, DAL, Zanon, N, De Sá, RAM, Acacio, GL, Ogeda, E, Belem, TMLOU, Chmait, RH, Kontopoulos, E & Quintero, RA 2014, 'Fetoscopic single-layer repair of open spina bifida using a cellulose patch: Preliminary clinical experience', Journal of Maternal-Fetal and Neonatal Medicine, vol. 27, no. 16, pp. 1613-1619. https://doi.org/10.3109/14767058.2013.871701
Pedreira, Denise A L ; Zanon, Nelci ; De Sá, Renato A M ; Acacio, Gregório L. ; Ogeda, Edilson ; Belem, Teresa M L O U ; Chmait, Ramen H. ; Kontopoulos, Eftichia ; Quintero, Ruben A. / Fetoscopic single-layer repair of open spina bifida using a cellulose patch : Preliminary clinical experience. In: Journal of Maternal-Fetal and Neonatal Medicine. 2014 ; Vol. 27, No. 16. pp. 1613-1619.
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