Fetoscopic single-layer repair of open spina bifida using a cellulose patch: Preliminary clinical experience

Denise A.L. Pedreira, Nelci Zanon, Renato A.M. De Sá, Gregório L. Acacio, Edilson Ogeda, Teresa M.L.O.U. Belem, Ramen H. Chmait, Eftichia Kontopoulos, Ruben A. Quintero

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Objective: To report our preliminary clinical experience in the antenatal correction of open spina bifida (OSB) using a fetoscopic approach and a simplified closure technique. Methods: Four fetuses with lumbar-sacral defects were operated in utero from 25 to 27 weeks. Surgeries were performed percutaneously under general anesthesia using three trocars and partial carbon dioxide insufflation. After dissection of the neural placode, the surrounding skin was closed over a cellulose patch using a single continuous stitch. Results: Surgical closure was successful in three of the four cases. All successful cases showed improvement of the hindbrain herniation and no neonatal neurosurgical repair was required in two cases. Delivery occurred between 31 and 33 weeks, and no fetal or neonatal deaths occurred. Ventriculoperitoneal shunting was not needed in two out of the 3 successful cases. Conclusions: Our preliminary experience suggests that definitive fetoscopic repair of OSB is feasible using our innovative surgical technique. A phase I trial for the fetoscopic correction of OSB with this technique is currently being conducted.

Original languageEnglish (US)
Pages (from-to)1613-1619
Number of pages7
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number16
StatePublished - Nov 1 2014
Externally publishedYes


  • Cellulose
  • Fetal therapy
  • Fetoscopy
  • Meningomyelocele
  • Myelomeningocele
  • Spina bifida

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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