Fetal surgery in complicated monoamniotic pregnancies: Case series and systematic review of the literature

Suzanne H P Peeters, Roland Devlieger, Johanna M. Middeldorp, Philip Dekoninck, Jan Deprest, Enrico Lopriore, Liesbeth Lewi, Frans J. Klumper, Eftichia Kontopoulos, Ruben Quintero, Dick Oepkes

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: This study aimed to analyze perinatal outcome in monoamniotic (MA) pregnancies that underwent antenatal surgical interventions for fetal complications. Methods: Review of all MA pregnancies treated with antenatal surgical interventions in three fetal treatment centers between 2000 and 2013. Indications were twin-twin transfusion syndrome, twin reversed arterial perfusion sequence, discordant anomalies, or elective reduction. We analyzed associations between indication, type of intervention, perinatal survival, and gestational age (GA) at birth and compared our results with a systematic review of the literature. Results: Fifty-eight MA pregnancies were included. Median GA at treatment was 18.0weeks (range: 13.1-33.0). Procedures included cord coagulation plus transection (n=42), cord coagulation without transection (n=7), laser coagulation of placental anastomoses (n=7), and one case each with interstitial laser and radiofrequency ablation. Median GA at birth was 34weeks (range 16.0-41.0), and 75% (53/71) of fetuses intended to survive indeed survived. Literature review included 20 articles, reporting on a total of 45 cases of surgically treated MA pregnancies, showing similar outcome results. Conclusion: We present the largest series concerning surgical interventions in complicated MA pregnancies. Despite being rare in experienced hands, a 75% survival is achieved. Collaboration between centers, data sharing, and benchmarking may further improve outcome.

Original languageEnglish
Pages (from-to)586-591
Number of pages6
JournalPrenatal Diagnosis
Volume34
Issue number6
DOIs
StatePublished - Jan 1 2014

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Pregnancy
Fetofetal Transfusion
Gestational Age
Parturition
Laser Coagulation
Benchmarking
Information Dissemination
Laser Therapy
Fetus
Perfusion
Therapeutics

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynecology

Cite this

Peeters, S. H. P., Devlieger, R., Middeldorp, J. M., Dekoninck, P., Deprest, J., Lopriore, E., ... Oepkes, D. (2014). Fetal surgery in complicated monoamniotic pregnancies: Case series and systematic review of the literature. Prenatal Diagnosis, 34(6), 586-591. https://doi.org/10.1002/pd.4353

Fetal surgery in complicated monoamniotic pregnancies : Case series and systematic review of the literature. / Peeters, Suzanne H P; Devlieger, Roland; Middeldorp, Johanna M.; Dekoninck, Philip; Deprest, Jan; Lopriore, Enrico; Lewi, Liesbeth; Klumper, Frans J.; Kontopoulos, Eftichia; Quintero, Ruben; Oepkes, Dick.

In: Prenatal Diagnosis, Vol. 34, No. 6, 01.01.2014, p. 586-591.

Research output: Contribution to journalArticle

Peeters, SHP, Devlieger, R, Middeldorp, JM, Dekoninck, P, Deprest, J, Lopriore, E, Lewi, L, Klumper, FJ, Kontopoulos, E, Quintero, R & Oepkes, D 2014, 'Fetal surgery in complicated monoamniotic pregnancies: Case series and systematic review of the literature', Prenatal Diagnosis, vol. 34, no. 6, pp. 586-591. https://doi.org/10.1002/pd.4353
Peeters SHP, Devlieger R, Middeldorp JM, Dekoninck P, Deprest J, Lopriore E et al. Fetal surgery in complicated monoamniotic pregnancies: Case series and systematic review of the literature. Prenatal Diagnosis. 2014 Jan 1;34(6):586-591. https://doi.org/10.1002/pd.4353
Peeters, Suzanne H P ; Devlieger, Roland ; Middeldorp, Johanna M. ; Dekoninck, Philip ; Deprest, Jan ; Lopriore, Enrico ; Lewi, Liesbeth ; Klumper, Frans J. ; Kontopoulos, Eftichia ; Quintero, Ruben ; Oepkes, Dick. / Fetal surgery in complicated monoamniotic pregnancies : Case series and systematic review of the literature. In: Prenatal Diagnosis. 2014 ; Vol. 34, No. 6. pp. 586-591.
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