Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin

Fu Hsiung Lin, Jing Yi Lin, Ravindra D. Gupta, Joshua A. Tournas, James A. Burch, M. Angelica Selim, Nancy A. Monteiro-Riviere, James M Grichnik, Jan Zielinski, Sheldon R. Pinnell

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

Ferulic acid is a potent ubiquitous plant antioxidant. Its incorporation into a topical solution of 15% L-ascorbic acid and 1% α-tocopherol improved chemical stability of the vitamins (C + E) and doubled photoprotection to solar-simulated irradiation of skin from 4-fold to approximately 8-fold as measured by both erythema and sunburn cell formation. Inhibition of apoptosis was associated with reduced induction of caspase-3 and caspase-7. This antioxidant formulation efficiently reduced thymine dimer formation. This combination of pure natural low molecular weight antioxidants provides meaningful synergistic protection against oxidative stress in skin and should be useful for protection against photoaging and skin cancer.

Original languageEnglish
Pages (from-to)826-832
Number of pages7
JournalJournal of Investigative Dermatology
Volume125
Issue number4
DOIs
StatePublished - Oct 1 2005
Externally publishedYes

Fingerprint

ferulic acid
Vitamin E
Ascorbic Acid
Skin
Antioxidants
Sunburn
Caspase 7
Skin Aging
Pyrimidine Dimers
Oxidative stress
Tocopherols
Chemical stability
Skin Neoplasms
Erythema
Caspase 3
Oxidative Stress
Molecular Weight
Molecular weight
Irradiation
Apoptosis

Keywords

  • Antioxidant
  • Ferulic acid
  • Photoprotection
  • Vitamin C
  • Vitamin E

ASJC Scopus subject areas

  • Dermatology

Cite this

Lin, F. H., Lin, J. Y., Gupta, R. D., Tournas, J. A., Burch, J. A., Selim, M. A., ... Pinnell, S. R. (2005). Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. Journal of Investigative Dermatology, 125(4), 826-832. https://doi.org/10.1111/j.0022-202X.2005.23768.x

Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. / Lin, Fu Hsiung; Lin, Jing Yi; Gupta, Ravindra D.; Tournas, Joshua A.; Burch, James A.; Selim, M. Angelica; Monteiro-Riviere, Nancy A.; Grichnik, James M; Zielinski, Jan; Pinnell, Sheldon R.

In: Journal of Investigative Dermatology, Vol. 125, No. 4, 01.10.2005, p. 826-832.

Research output: Contribution to journalArticle

Lin, FH, Lin, JY, Gupta, RD, Tournas, JA, Burch, JA, Selim, MA, Monteiro-Riviere, NA, Grichnik, JM, Zielinski, J & Pinnell, SR 2005, 'Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin', Journal of Investigative Dermatology, vol. 125, no. 4, pp. 826-832. https://doi.org/10.1111/j.0022-202X.2005.23768.x
Lin, Fu Hsiung ; Lin, Jing Yi ; Gupta, Ravindra D. ; Tournas, Joshua A. ; Burch, James A. ; Selim, M. Angelica ; Monteiro-Riviere, Nancy A. ; Grichnik, James M ; Zielinski, Jan ; Pinnell, Sheldon R. / Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. In: Journal of Investigative Dermatology. 2005 ; Vol. 125, No. 4. pp. 826-832.
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