Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin

Fu Hsiung Lin, Jing Yi Lin, Ravindra D. Gupta, Joshua A. Tournas, James A. Burch, M. Angelica Selim, Nancy A. Monteiro-Riviere, James M. Grichnik, Jan Zielinski, Sheldon R. Pinnell

Research output: Contribution to journalArticle

179 Scopus citations

Abstract

Ferulic acid is a potent ubiquitous plant antioxidant. Its incorporation into a topical solution of 15% L-ascorbic acid and 1% α-tocopherol improved chemical stability of the vitamins (C + E) and doubled photoprotection to solar-simulated irradiation of skin from 4-fold to approximately 8-fold as measured by both erythema and sunburn cell formation. Inhibition of apoptosis was associated with reduced induction of caspase-3 and caspase-7. This antioxidant formulation efficiently reduced thymine dimer formation. This combination of pure natural low molecular weight antioxidants provides meaningful synergistic protection against oxidative stress in skin and should be useful for protection against photoaging and skin cancer.

Original languageEnglish (US)
Pages (from-to)826-832
Number of pages7
JournalJournal of Investigative Dermatology
Volume125
Issue number4
DOIs
StatePublished - Oct 1 2005

Keywords

  • Antioxidant
  • Ferulic acid
  • Photoprotection
  • Vitamin C
  • Vitamin E

ASJC Scopus subject areas

  • Dermatology

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    Lin, F. H., Lin, J. Y., Gupta, R. D., Tournas, J. A., Burch, J. A., Selim, M. A., Monteiro-Riviere, N. A., Grichnik, J. M., Zielinski, J., & Pinnell, S. R. (2005). Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. Journal of Investigative Dermatology, 125(4), 826-832. https://doi.org/10.1111/j.0022-202X.2005.23768.x