Ferrugination caused by Monsel's solution. Clinical observations and experimentations

K. Amazon, M. J. Robinson, A. M. Rywlin

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Ferrugination of fibrin, dermal collagen, and striated muscle fibers may result from the application of Monsel's solution (20% ferric subsulfate) for hemostasis to wounds caused by excisions of skin. The collagen fibers in the dermis are coated with a slightly refractile, graybrown substance which is strongly positive with Perl's reaction for iron. Ferruginated collagen fibers are eliminated through the epidermis as the epidermis regenerates. Some of the ferruginated fibers become calcified. Siderophages are present in these and adjacent areas. Seepage of Monsel's solution into deeper tissues at the site of biopsy may result in ferrugination of skeletal muscle, perichondrium, and even cartilage. We applied Monsel's solution to biopsy sites caused experimentally in a rabbit and confirmed the capacity of the solution to produce ferrugination of collagen fibers and skeletal muscle. Ferrugination of collagen fibers becomes less pronounced as the wounds heal and as iron pigment is taken up by macrophages. Ferruginated fibers of skeletal muscle act as foreign bodies to elicit a granulomatous reaction. Comparison of biopsy sites to which Monsel's solution had been applied with biopsy sites to which the solution had not been applied indicates that the substance does not seem to interfere with the rate of epidermal regeneration. However, when there is injury to skeletal muscle and other deep tissues by Monsel's solution, an inflammatory reaction persists at these sites for weeks.

Original languageEnglish
Pages (from-to)197-205
Number of pages9
JournalAmerican Journal of Dermatopathology
Volume2
Issue number3
StatePublished - Dec 1 1980
Externally publishedYes

Fingerprint

Collagen
Biopsy
Skeletal Muscle Fibers
Epidermis
Wounds and Injuries
Skeletal Muscle
Iron
Skin
Striated Muscle
Dermis
Foreign Bodies
Hemostasis
Fibrin
Cartilage
ferric subsulfate solution
Regeneration
Macrophages
Rabbits

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

Cite this

Ferrugination caused by Monsel's solution. Clinical observations and experimentations. / Amazon, K.; Robinson, M. J.; Rywlin, A. M.

In: American Journal of Dermatopathology, Vol. 2, No. 3, 01.12.1980, p. 197-205.

Research output: Contribution to journalArticle

Amazon, K. ; Robinson, M. J. ; Rywlin, A. M. / Ferrugination caused by Monsel's solution. Clinical observations and experimentations. In: American Journal of Dermatopathology. 1980 ; Vol. 2, No. 3. pp. 197-205.
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