Ferrociphenol lipid nanocapsule delivery by mesenchymal stromal cells in brain tumor therapy

Mathilde Roger, Anne Clavreul, Ngoc Trinh Huynh, Catherine Passirani, Paul C Schiller, Anne Vessires, Claudia Montero-Menei, Philippe Menei

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

The prognosis of patients with malignant glioma remains extremely poor despite surgery and improvements in radio- and chemo-therapies. Thus, treatment strategies that specifically target these tumors have the potential to greatly improve therapeutic outcomes. "Marrow-isolated adult multilineage inducible" cells (MIAMI cells) are a subpopulation of mesenchymal stromal cells (MSCs) which possess the ability to migrate to brain tumors. We have previously shown that MIAMI cells were able to efficiently incorporate lipid nanocapsules (LNCs) without altering either their stem cell properties or their migration capacity. In this study, we assessed whether the cytotoxic effects of MIAMI cells loaded with LNCs containing an organometallic complex (ferrociphenol or Fc-diOH) could be used to treat brain tumors. The results showed that MIAMI cells internalized Fc-diOH-LNCs and that this internalization did not induce MIAMI cell death. Furthermore, Fc-diOH-LNC-loaded MIAMI cells produced a cytotoxic effect on U87MG glioma cells in vitro. This cytotoxic effect was validated in vivo after intratumoral injection of Fc-diOH-LNC-loaded MIAMI cells in a heterotopic U87MG glioma model in nude mice. These promising results open up a new field of treatment in which cellular vehicles and nanoparticles can be combined to treat brain tumors.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume423
Issue number1
DOIs
StatePublished - Feb 14 2012

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Keywords

  • Glioma
  • Mesenchymal stromal cells
  • Nanocarriers
  • Organometallic compound

ASJC Scopus subject areas

  • Pharmaceutical Science

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