Abstract
Purpose: To evaluate a femtosecond laser system to create the capsulotomy. Setting: Porcine and cadaver eye studies were performed at OptiMedica Corp., Santa Clara, California, USA; the human trial was performed at the Centro Laser, Santo Domingo, Dominican Republic. Design: Experimental and clinical study. Methods: Capsulotomies performed by an optical coherence tomography-guided femtosecond laser were evaluated in porcine and human cadaver eyes. Subsequently, the procedure was performed in 39 patients as part of a prospective randomized study of femtosecond laser-assisted cataract surgery. The accuracy of the capsulotomy size, shape, and centration were quantified and capsulotomy strength was assessed in the porcine eyes. Results: Laser-created capsulotomies were significantly more precise in size and shape than manually created capsulorhexes. In the patient eyes, the deviation from the intended diameter of the resected capsule disk was 29 μm ± 26 (SD) for the laser technique and 337 ± 258 μm for the manual technique. The mean deviation from circularity was 6% and 20%, respectively. The center of the laser capsulotomies was within 77 ± 47 μm of the intended position. All capsulotomies were complete, with no radial nicks or tears. The strength of laser capsulotomies (porcine subgroup) decreased with increasing pulse energy: 152 ± 21 mN for 3 μJ, 121 ± 16 mN for 6 μJ, and 113 ± 23 mN for 10 μJ. The strength of the manual capsulorhexes was 65 ± 21 mN. Conclusion: The femtosecond laser produced capsulotomies that were more precise, accurate, reproducible, and stronger than those created with the conventional manual technique.
| Original language | English |
|---|---|
| Pages (from-to) | 1189-1198 |
| Number of pages | 10 |
| Journal | Journal of Cataract and Refractive Surgery |
| Volume | 37 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2011 |
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ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Surgery
Cite this
Femtosecond laser capsulotomy. / Friedman, Neil J.; Palanker, Daniel V.; Schuele, Georg; Andersen, Dan; Marcellino, George; Seibel, Barry S.; Batlle, Juan; Feliz, Rafael; Talamo, Jonathan H.; Blumenkranz, Mark S.; Culbertson, William W.
In: Journal of Cataract and Refractive Surgery, Vol. 37, No. 7, 01.07.2011, p. 1189-1198.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Femtosecond laser capsulotomy
AU - Friedman, Neil J.
AU - Palanker, Daniel V.
AU - Schuele, Georg
AU - Andersen, Dan
AU - Marcellino, George
AU - Seibel, Barry S.
AU - Batlle, Juan
AU - Feliz, Rafael
AU - Talamo, Jonathan H.
AU - Blumenkranz, Mark S.
AU - Culbertson, William W
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Purpose: To evaluate a femtosecond laser system to create the capsulotomy. Setting: Porcine and cadaver eye studies were performed at OptiMedica Corp., Santa Clara, California, USA; the human trial was performed at the Centro Laser, Santo Domingo, Dominican Republic. Design: Experimental and clinical study. Methods: Capsulotomies performed by an optical coherence tomography-guided femtosecond laser were evaluated in porcine and human cadaver eyes. Subsequently, the procedure was performed in 39 patients as part of a prospective randomized study of femtosecond laser-assisted cataract surgery. The accuracy of the capsulotomy size, shape, and centration were quantified and capsulotomy strength was assessed in the porcine eyes. Results: Laser-created capsulotomies were significantly more precise in size and shape than manually created capsulorhexes. In the patient eyes, the deviation from the intended diameter of the resected capsule disk was 29 μm ± 26 (SD) for the laser technique and 337 ± 258 μm for the manual technique. The mean deviation from circularity was 6% and 20%, respectively. The center of the laser capsulotomies was within 77 ± 47 μm of the intended position. All capsulotomies were complete, with no radial nicks or tears. The strength of laser capsulotomies (porcine subgroup) decreased with increasing pulse energy: 152 ± 21 mN for 3 μJ, 121 ± 16 mN for 6 μJ, and 113 ± 23 mN for 10 μJ. The strength of the manual capsulorhexes was 65 ± 21 mN. Conclusion: The femtosecond laser produced capsulotomies that were more precise, accurate, reproducible, and stronger than those created with the conventional manual technique.
AB - Purpose: To evaluate a femtosecond laser system to create the capsulotomy. Setting: Porcine and cadaver eye studies were performed at OptiMedica Corp., Santa Clara, California, USA; the human trial was performed at the Centro Laser, Santo Domingo, Dominican Republic. Design: Experimental and clinical study. Methods: Capsulotomies performed by an optical coherence tomography-guided femtosecond laser were evaluated in porcine and human cadaver eyes. Subsequently, the procedure was performed in 39 patients as part of a prospective randomized study of femtosecond laser-assisted cataract surgery. The accuracy of the capsulotomy size, shape, and centration were quantified and capsulotomy strength was assessed in the porcine eyes. Results: Laser-created capsulotomies were significantly more precise in size and shape than manually created capsulorhexes. In the patient eyes, the deviation from the intended diameter of the resected capsule disk was 29 μm ± 26 (SD) for the laser technique and 337 ± 258 μm for the manual technique. The mean deviation from circularity was 6% and 20%, respectively. The center of the laser capsulotomies was within 77 ± 47 μm of the intended position. All capsulotomies were complete, with no radial nicks or tears. The strength of laser capsulotomies (porcine subgroup) decreased with increasing pulse energy: 152 ± 21 mN for 3 μJ, 121 ± 16 mN for 6 μJ, and 113 ± 23 mN for 10 μJ. The strength of the manual capsulorhexes was 65 ± 21 mN. Conclusion: The femtosecond laser produced capsulotomies that were more precise, accurate, reproducible, and stronger than those created with the conventional manual technique.
UR - http://www.scopus.com/inward/record.url?scp=79959550933&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959550933&partnerID=8YFLogxK
U2 - 10.1016/j.jcrs.2011.04.022
DO - 10.1016/j.jcrs.2011.04.022
M3 - Article
C2 - 21700099
AN - SCOPUS:79959550933
VL - 37
SP - 1189
EP - 1198
JO - Journal of Cataract and Refractive Surgery
JF - Journal of Cataract and Refractive Surgery
SN - 0886-3350
IS - 7
ER -