Abstract
Background: Femtosecond laser technology (IntraLase, Irvine, CA, USA) has been introduced in corneal surgery, opening a new frontier and providing a new surgical modality. The purpose of this study is to present a series of patients with keratitis after Femtosecond-assisted diagnostic corneal biopsies (FAB). Methods: Four patients with progressive keratitis - despite intensive broad-spectrum topical antimicrobial therapy, or progressive stromal infiltration inaccessible to corneal scrapings - underwent femtosecond-assisted diagnostic corneal biopsy. A corneal specimen was obtained using the Femtosecond laser (IntraLase), including both clinically infected and adjacent non-infected clear corneal tissue. A combination of lamellar and keratoplasty treatment parameters were used. Results: Corneal specimens of 3 mm diameter and 120 to 200 μm thickness were obtained in all patients. No intra- or early post-operative complications related to the procedure were found. In all patients, adequate specimens were submitted for cultures, smears, and permanent section staining. Conclusions: In this small case series of patients with undiagnosed keratitis, femtosecond-assisted diagnostic corneal biopsy (FAB) obtained adequate specimens without intra- or early post-operative complications, related to the procedure.
| Original language | English |
|---|---|
| Pages (from-to) | 759-762 |
| Number of pages | 4 |
| Journal | Graefe's Archive for Clinical and Experimental Ophthalmology |
| Volume | 246 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2008 |
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Keywords
- Corneal biopsy
- Femtosecond laser
- Keratitis
ASJC Scopus subject areas
- Ophthalmology
Cite this
Femtosecond-assisted diagnostic corneal biopsy (FAB) in keratitis. / Yoo, Sonia H; Kymionis, George D.; O'Brien, Terrence; Ide, Takeshi; Culbertson, William W; Alfonso, Eduardo C.
In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 246, No. 5, 01.05.2008, p. 759-762.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Femtosecond-assisted diagnostic corneal biopsy (FAB) in keratitis
AU - Yoo, Sonia H
AU - Kymionis, George D.
AU - O'Brien, Terrence
AU - Ide, Takeshi
AU - Culbertson, William W
AU - Alfonso, Eduardo C
PY - 2008/5/1
Y1 - 2008/5/1
N2 - Background: Femtosecond laser technology (IntraLase, Irvine, CA, USA) has been introduced in corneal surgery, opening a new frontier and providing a new surgical modality. The purpose of this study is to present a series of patients with keratitis after Femtosecond-assisted diagnostic corneal biopsies (FAB). Methods: Four patients with progressive keratitis - despite intensive broad-spectrum topical antimicrobial therapy, or progressive stromal infiltration inaccessible to corneal scrapings - underwent femtosecond-assisted diagnostic corneal biopsy. A corneal specimen was obtained using the Femtosecond laser (IntraLase), including both clinically infected and adjacent non-infected clear corneal tissue. A combination of lamellar and keratoplasty treatment parameters were used. Results: Corneal specimens of 3 mm diameter and 120 to 200 μm thickness were obtained in all patients. No intra- or early post-operative complications related to the procedure were found. In all patients, adequate specimens were submitted for cultures, smears, and permanent section staining. Conclusions: In this small case series of patients with undiagnosed keratitis, femtosecond-assisted diagnostic corneal biopsy (FAB) obtained adequate specimens without intra- or early post-operative complications, related to the procedure.
AB - Background: Femtosecond laser technology (IntraLase, Irvine, CA, USA) has been introduced in corneal surgery, opening a new frontier and providing a new surgical modality. The purpose of this study is to present a series of patients with keratitis after Femtosecond-assisted diagnostic corneal biopsies (FAB). Methods: Four patients with progressive keratitis - despite intensive broad-spectrum topical antimicrobial therapy, or progressive stromal infiltration inaccessible to corneal scrapings - underwent femtosecond-assisted diagnostic corneal biopsy. A corneal specimen was obtained using the Femtosecond laser (IntraLase), including both clinically infected and adjacent non-infected clear corneal tissue. A combination of lamellar and keratoplasty treatment parameters were used. Results: Corneal specimens of 3 mm diameter and 120 to 200 μm thickness were obtained in all patients. No intra- or early post-operative complications related to the procedure were found. In all patients, adequate specimens were submitted for cultures, smears, and permanent section staining. Conclusions: In this small case series of patients with undiagnosed keratitis, femtosecond-assisted diagnostic corneal biopsy (FAB) obtained adequate specimens without intra- or early post-operative complications, related to the procedure.
KW - Corneal biopsy
KW - Femtosecond laser
KW - Keratitis
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UR - http://www.scopus.com/inward/citedby.url?scp=42049088522&partnerID=8YFLogxK
U2 - 10.1007/s00417-008-0785-8
DO - 10.1007/s00417-008-0785-8
M3 - Article
C2 - 18322693
AN - SCOPUS:42049088522
VL - 246
SP - 759
EP - 762
JO - Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie
JF - Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie
SN - 0065-6100
IS - 5
ER -