Features of an autoimmune process in mid-dermal elastolysis

Robert S. Kirsner, Vincent Falanga

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Mid-dermal elastolysis is a rare disorder that is manifested clinically by wrinkling and histologically by the selective absence of elastic fibers in the mid dermis. We describe a young woman who developed abnormal wrinkling after augmentation mammoplasty with silicone implants. Histologic examination confirmed the diagnosis of mid-dermal elastolysis. In addition, a positive antinuclear antibody titer and a false-positive Lyme titer were subsequently detected. In a previously reported case a patient who had mid-dermal elastolysis also had an unusual false-positive pattern for Lyme disease. Silicone mammoplasty has been associated with connective tissue diseases. This report adds mid-dermal elastolysis to the list of diseases associated with augmentation mammoplasty and, along with the presence of autoantibodies, supports autoimmune involvement in mid-dermal elastolysis.

Original languageEnglish (US)
Pages (from-to)832-834
Number of pages3
JournalJournal of the American Academy of Dermatology
Issue number5
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Dermatology


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