Abstract
The objective of this study was to compare textural to attenuation/ backscatter indices of fatty liver correlated to histology to suggest the better approach for an objective noninvasive ultrasonic "biopsy". Forty-four patients with severe steatosis by histopathology were selected for this study. Ten patients had "pure" fatty liver and 34 had in addition fibrosis and/or inflammation. Ultrasonic images were acquired before needle insertion. The ROI used for biopsy was marked on the ultrasonic image and characterized by three attenuation/backscatter and 18 textural related indices. Statistical analysis was performed using logistic regression. Twenty-one healthy subjects served as control. The attenuation/backscatter indices were superior to textural indices in differentiating between the categories studied. Pure fatty livers could be reliably identified (AUC = 1, SE = 0). Among the 18 textural indices, "co-occurrences sum entropy" and "co-occurrences entropy" presented the best results. Attenuation/backscatter based indices appear to have better potential than the textural based indices. (E-mail: D_Gaitini@Rambam. Health.Gov.IL).
Original language | English (US) |
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Pages (from-to) | 1321-1327 |
Number of pages | 7 |
Journal | Ultrasound in Medicine and Biology |
Volume | 30 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2004 |
Externally published | Yes |
Keywords
- Acoustic attenuation
- Biopsy
- Diffuse liver disease
- Histology
- Needle biopsy
- Steatosis
- Texture
- Ultrasound
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging