Abstract
The objective of this study was to compare textural to attenuation/ backscatter indices of fatty liver correlated to histology to suggest the better approach for an objective noninvasive ultrasonic "biopsy". Forty-four patients with severe steatosis by histopathology were selected for this study. Ten patients had "pure" fatty liver and 34 had in addition fibrosis and/or inflammation. Ultrasonic images were acquired before needle insertion. The ROI used for biopsy was marked on the ultrasonic image and characterized by three attenuation/backscatter and 18 textural related indices. Statistical analysis was performed using logistic regression. Twenty-one healthy subjects served as control. The attenuation/backscatter indices were superior to textural indices in differentiating between the categories studied. Pure fatty livers could be reliably identified (AUC = 1, SE = 0). Among the 18 textural indices, "co-occurrences sum entropy" and "co-occurrences entropy" presented the best results. Attenuation/backscatter based indices appear to have better potential than the textural based indices. (E-mail: D_Gaitini@Rambam. Health.Gov.IL).
| Original language | English |
|---|---|
| Pages (from-to) | 1321-1327 |
| Number of pages | 7 |
| Journal | Ultrasound in Medicine and Biology |
| Volume | 30 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2004 |
| Externally published | Yes |
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Keywords
- Acoustic attenuation
- Biopsy
- Diffuse liver disease
- Histology
- Needle biopsy
- Steatosis
- Texture
- Ultrasound
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Feasibility study of ultrasonic fatty liver biopsy : Texture vs. attenuation and backscatter. / Gaitini, Diana; Baruch, Yaacov; Ghersin, Eduard; Veitsman, Ella; Kerner, Hedvika; Shalem, Bruria; Yaniv, Geva; Sarfaty, Chen; Azhari, Haim.
In: Ultrasound in Medicine and Biology, Vol. 30, No. 10, 01.10.2004, p. 1321-1327.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Feasibility study of ultrasonic fatty liver biopsy
T2 - Texture vs. attenuation and backscatter
AU - Gaitini, Diana
AU - Baruch, Yaacov
AU - Ghersin, Eduard
AU - Veitsman, Ella
AU - Kerner, Hedvika
AU - Shalem, Bruria
AU - Yaniv, Geva
AU - Sarfaty, Chen
AU - Azhari, Haim
PY - 2004/10/1
Y1 - 2004/10/1
N2 - The objective of this study was to compare textural to attenuation/ backscatter indices of fatty liver correlated to histology to suggest the better approach for an objective noninvasive ultrasonic "biopsy". Forty-four patients with severe steatosis by histopathology were selected for this study. Ten patients had "pure" fatty liver and 34 had in addition fibrosis and/or inflammation. Ultrasonic images were acquired before needle insertion. The ROI used for biopsy was marked on the ultrasonic image and characterized by three attenuation/backscatter and 18 textural related indices. Statistical analysis was performed using logistic regression. Twenty-one healthy subjects served as control. The attenuation/backscatter indices were superior to textural indices in differentiating between the categories studied. Pure fatty livers could be reliably identified (AUC = 1, SE = 0). Among the 18 textural indices, "co-occurrences sum entropy" and "co-occurrences entropy" presented the best results. Attenuation/backscatter based indices appear to have better potential than the textural based indices. (E-mail: D_Gaitini@Rambam. Health.Gov.IL).
AB - The objective of this study was to compare textural to attenuation/ backscatter indices of fatty liver correlated to histology to suggest the better approach for an objective noninvasive ultrasonic "biopsy". Forty-four patients with severe steatosis by histopathology were selected for this study. Ten patients had "pure" fatty liver and 34 had in addition fibrosis and/or inflammation. Ultrasonic images were acquired before needle insertion. The ROI used for biopsy was marked on the ultrasonic image and characterized by three attenuation/backscatter and 18 textural related indices. Statistical analysis was performed using logistic regression. Twenty-one healthy subjects served as control. The attenuation/backscatter indices were superior to textural indices in differentiating between the categories studied. Pure fatty livers could be reliably identified (AUC = 1, SE = 0). Among the 18 textural indices, "co-occurrences sum entropy" and "co-occurrences entropy" presented the best results. Attenuation/backscatter based indices appear to have better potential than the textural based indices. (E-mail: D_Gaitini@Rambam. Health.Gov.IL).
KW - Acoustic attenuation
KW - Biopsy
KW - Diffuse liver disease
KW - Histology
KW - Needle biopsy
KW - Steatosis
KW - Texture
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=9644256057&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=9644256057&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2004.08.001
DO - 10.1016/j.ultrasmedbio.2004.08.001
M3 - Article
C2 - 15582231
AN - SCOPUS:9644256057
VL - 30
SP - 1321
EP - 1327
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
SN - 0301-5629
IS - 10
ER -