Feasibility of allogeneic stem cells for heart regeneration

W. Balkan, V. Y. Suncion, K. S. Telukuntla, J. M. Hare

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Stem cell therapy for heart disease is currently one of the most exciting ideas in regenerative medicine, and allogeneic mesenchymal stem cells (MSCs) are emerging as a lead candidate for cell-based therapeutics. These cells promote healing, have an excellent safety record in preclinical and clinical trials, and are readily available in large quantities. However, there is some controversy regarding their interaction with the host immune system. Allogeneic MSCs are currently in clinical trials as a cell therapy for heart disease, including one trial where the efficacy of allogeneic and autologous MSCs is directly compared. This chapter examines the current and future possibilities of using allogeneic MSCs for cardiac regeneration therapy.

Original languageEnglish (US)
Title of host publicationCardiac Regeneration and Repair
PublisherElsevier Ltd
Pages207-235
Number of pages29
Volume1
ISBN (Print)9780857096586
DOIs
StatePublished - Feb 1 2014

Keywords

  • Allogeneic
  • Cardiac
  • Mesenchymal stem cells
  • Myocardial infarction

ASJC Scopus subject areas

  • Medicine(all)
  • Dentistry(all)

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  • Cite this

    Balkan, W., Suncion, V. Y., Telukuntla, K. S., & Hare, J. M. (2014). Feasibility of allogeneic stem cells for heart regeneration. In Cardiac Regeneration and Repair (Vol. 1, pp. 207-235). Elsevier Ltd. https://doi.org/10.1533/9780857096708.2.207