Feasibility and clinical utility of ultra-widefield indocyanine green angiography

Michael A. Klufas, Nicolas A. Yannuzzi, Claudine E. Pang, Sowmya Srinivas, Srinivas R. Sadda, K. Bailey Freund, Szilárd Kiss

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Purpose: To evaluate the feasibility and clinical utility of a novel noncontact scanning laser ophthalmoscope-based ultra-widefield indocyanine green angiographic system. Methods: Ultra-widefield indocyanine green angiographic images were captured using a modified Optos P200Tx that produced high-resolution images of the choroidal vasculature with up to a 200° field. Ultra-widefield indocyanine green angiography was performed on patients with a variety of retinal conditions to assess utility of this imaging technique for diagnostic purposes and disease treatment monitoring. Results: Ultra-widefield indocyanine green angiography was performed on 138 eyes of 69 patients. Mean age was 58 ± 16.9 years (range, 24-85 years). The most common ocular pathologies imaged included central serous chorioretinopathy (24 eyes), uveitis (various subtypes, 16 eyes), age-related macular degeneration (12 eyes), and polypoidal choroidal vasculopathy (4 eyes). In all eyes evaluated with ultra-widefield indocyanine green angiography, high-resolution images of choroidal and retinal circulation were obtained with sufficient detail out to 200° of the fundus. Conclusion: In this series of 138 eyes, scanning laser ophthalmoscope-based ultra-widefield indocyanine green angiography was clinically practical and provided detailed images of both the central and peripheral choroidal circulation. Future studies are needed to refine the clinical value of this imaging modality and the significance of peripheral choroidal vascular changes in the diagnosis, monitoring, and treatment of ocular diseases.

Original languageEnglish (US)
Pages (from-to)508-520
Number of pages13
JournalRetina
Volume35
Issue number3
DOIs
StatePublished - Mar 10 2015
Externally publishedYes

Keywords

  • acute zonal occult outer retinopathy
  • age-related macular degeneration
  • birdshot chorioretinopathy
  • central serous chorioretinopathy
  • imaging
  • indocyanine green angiography
  • multifocal choroiditis
  • polypoidal choroidal vasculopathy
  • retinal imaging
  • sarcoidosis
  • syphilis
  • ultra-widefield
  • ultra-widefield imaging
  • wide-field
  • wide-field fluorescein angiography

ASJC Scopus subject areas

  • Ophthalmology

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