FcRL3 gene promoter variant is associated with peripheral arthritis in Crohn's disease

Juan Luis Mendoza, Raquel Lana, Maria C. Martin, Emilio G. De La Concha, Elena Urcelay, Manuel Diaz-Rubio, Maria T. Abreu, Adele A. Mitchell

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background: The mechanisms responsible for the pathogenesis of peripheral arthropathies (PA) in Crohn's disease (CD) are largely unknown, although many studies indicate that genetic and environmental factors are likely to contribute to risk. Methods: Because variants in the Fc receptor-like 3 (FcRL3) gene have recently been associated with rheumatoid arthritis and several other autoimmune diseases, we tested 2 FcRL3 promoter variants (-169 Cgt;T and -110 G>A) for association with PA in Spanish CD patients that were recruited from a single center and followed for at least 4 years (mean follow-up time, 11 years). Results: Among the 342 CD patients evaluated, there were 88 cases of peripheral arthropathy; 31 were classified as arthritis and 57 were classified as arthralgia. We used contingency tables and logistic regression to test for association between PA or either subtype and FcRL3 and other factors that have previously been associated with extraintestinal manifestations in CD. Conclusions: We found that female sex, colonic involvement, and the AA genotype at -110 G>A were associated with increased risk of both subtypes of PA, although the association appears to be stronger for arthritis than for arthralgia.

Original languageEnglish (US)
Pages (from-to)1351-1357
Number of pages7
JournalInflammatory bowel diseases
Volume15
Issue number9
DOIs
StatePublished - Nov 26 2009
Externally publishedYes

Keywords

  • Crohn's disease
  • FcRL3
  • Inflammatory bowel disease
  • Peripheral arthritis
  • Peripheral arthropathy

ASJC Scopus subject areas

  • Gastroenterology
  • Immunology and Allergy

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    Mendoza, J. L., Lana, R., Martin, M. C., De La Concha, E. G., Urcelay, E., Diaz-Rubio, M., Abreu, M. T., & Mitchell, A. A. (2009). FcRL3 gene promoter variant is associated with peripheral arthritis in Crohn's disease. Inflammatory bowel diseases, 15(9), 1351-1357. https://doi.org/10.1002/ibd.20895