Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes

Barbara Ludwig, Stefan Ludwig, Anja Steffen, Yvonne Knauf, Baruch Zimerman, Sophie Heinke, Susann Lehmann, Undine Schubert, Janine Schmid, Martina Bleyer, Uwe Schönmann, Clark K. Colton, Ezio Bonifacio, Michele Solimena, Andreas Reichel, Andrew V. Schally, Avi Rotem, Uriel Barkai, Helena Grinberg-Rashi, Franz Josef KaupYuval Avni, Peter Jones, Stefan R. Bornstein

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencap-sulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions.

Original languageEnglish (US)
Pages (from-to)11745-11750
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume114
Issue number44
DOIs
StatePublished - Oct 31 2017

Keywords

  • Beta-cell replacement
  • Diabetes
  • Immune barrier
  • Porcine islets

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes'. Together they form a unique fingerprint.

  • Cite this

    Ludwig, B., Ludwig, S., Steffen, A., Knauf, Y., Zimerman, B., Heinke, S., Lehmann, S., Schubert, U., Schmid, J., Bleyer, M., Schönmann, U., Colton, C. K., Bonifacio, E., Solimena, M., Reichel, A., Schally, A. V., Rotem, A., Barkai, U., Grinberg-Rashi, H., ... Bornstein, S. R. (2017). Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes. Proceedings of the National Academy of Sciences of the United States of America, 114(44), 11745-11750. https://doi.org/10.1073/pnas.1708420114