@article{2bae0a8e8fe544d3893ba0535b10ea72,
title = "Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes",
abstract = "Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencap-sulate islets from different sources that allow their survival and function without immunosuppression. Here we report successful and safe transplantation of porcine islets with a bioartificial pancreas device in diabetic primates without any immune suppression. This strategy should lead to pioneering clinical trials with xenotransplantation for treatment of diabetes and, thereby, represents a previously unidentified approach to efficient cell replacement for a broad spectrum of endocrine disorders and other organ dysfunctions.",
keywords = "Beta-cell replacement, Diabetes, Immune barrier, Porcine islets",
author = "Barbara Ludwig and Stefan Ludwig and Anja Steffen and Yvonne Knauf and Baruch Zimerman and Sophie Heinke and Susann Lehmann and Undine Schubert and Janine Schmid and Martina Bleyer and Uwe Sch{\"o}nmann and Colton, {Clark K.} and Ezio Bonifacio and Michele Solimena and Andreas Reichel and Schally, {Andrew V.} and Avi Rotem and Uriel Barkai and Helena Grinberg-Rashi and Kaup, {Franz Josef} and Yuval Avni and Peter Jones and Bornstein, {Stefan R.}",
note = "Funding Information: ACKNOWLEDGMENTS. We thank the German Primate Center for highly professional support of the nonhuman primate studies. This study was supported by the Deutsche Forschungsgemeinschaft (DFG) Grant BR1179 (to B.L.) and Grants CRC/TRR 127 and 205 (to B.L. and S.R.B.), the German Ministry for Education and Research to the German Centre for Diabetes Research (DZD e.V.), and the DFG-Center for Regenerative Therapies Dresden, Germany. Publisher Copyright: {\textcopyright} 2017, National Academy of Sciences. All rights reserved.",
year = "2017",
month = oct,
day = "31",
doi = "10.1073/pnas.1708420114",
language = "English (US)",
volume = "114",
pages = "11745--11750",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "44",
}