Fatty acid methyl esters as a potential therapy against cerebral ischemia

Reggie Hui Chao Lee, Juan Jose Goyanes Vasquez, Alexandre Couto E Silva, Daniel D. Klein, Stephen E. Valido, Joseph A. Chen, Francesca M. Lerner, Jake T. Neumann, Celeste Yin Chieh Wu, Hung Wen Lin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Saturated fatty acids have been traditionally thought to be detrimental in circulation. However, we describe the beneficial effects of palmitic and stearic acid methyl esters as it relates to neuroprotection and cerebral vasodilatory properties in global and focal cerebral ischemia. The methyl esterification of fatty acids is not prominent in nature. However, it seems to have biological activity related to neuroprotection/vasodilation. We will discuss the etiology of cerebral ischemia such as stroke and cardiac arrest in terms of current and future treatment modalitiesas it relates to fatty acid-based therapies. This review is based on the meeting presentation at the "The Journées Chevreul, Lipids & Brain III 2015" in Paris on 16-18 March, 2015.

Original languageEnglish (US)
Article numberD108
JournalOCL - Oilseeds and fats, crops and lipids
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

ischemia
Brain Ischemia
Esters
Fatty Acids
fatty acids
cardiac arrest
therapeutics
vasodilation
esterification
stearic acid
stroke
palmitic acid
saturated fatty acids
etiology
bioactive properties
Esterification
esters
Paris
Bioactivity
Heart Arrest

Keywords

  • Cerebral blood flow
  • Cerebral ischemia
  • Neuroprotection
  • Palmitic acid methyl ester
  • Protein arginine methyltransferase

ASJC Scopus subject areas

  • Food Science
  • Biochemistry
  • Agronomy and Crop Science

Cite this

Lee, R. H. C., Goyanes Vasquez, J. J., Couto E Silva, A., Klein, D. D., Valido, S. E., Chen, J. A., ... Wen Lin, H. (2016). Fatty acid methyl esters as a potential therapy against cerebral ischemia. OCL - Oilseeds and fats, crops and lipids, 23(1), [D108]. https://doi.org/10.1051/ocl/2015040

Fatty acid methyl esters as a potential therapy against cerebral ischemia. / Lee, Reggie Hui Chao; Goyanes Vasquez, Juan Jose; Couto E Silva, Alexandre; Klein, Daniel D.; Valido, Stephen E.; Chen, Joseph A.; Lerner, Francesca M.; Neumann, Jake T.; Wu, Celeste Yin Chieh; Wen Lin, Hung.

In: OCL - Oilseeds and fats, crops and lipids, Vol. 23, No. 1, D108, 01.01.2016.

Research output: Contribution to journalArticle

Lee, RHC, Goyanes Vasquez, JJ, Couto E Silva, A, Klein, DD, Valido, SE, Chen, JA, Lerner, FM, Neumann, JT, Wu, CYC & Wen Lin, H 2016, 'Fatty acid methyl esters as a potential therapy against cerebral ischemia', OCL - Oilseeds and fats, crops and lipids, vol. 23, no. 1, D108. https://doi.org/10.1051/ocl/2015040
Lee RHC, Goyanes Vasquez JJ, Couto E Silva A, Klein DD, Valido SE, Chen JA et al. Fatty acid methyl esters as a potential therapy against cerebral ischemia. OCL - Oilseeds and fats, crops and lipids. 2016 Jan 1;23(1). D108. https://doi.org/10.1051/ocl/2015040
Lee, Reggie Hui Chao ; Goyanes Vasquez, Juan Jose ; Couto E Silva, Alexandre ; Klein, Daniel D. ; Valido, Stephen E. ; Chen, Joseph A. ; Lerner, Francesca M. ; Neumann, Jake T. ; Wu, Celeste Yin Chieh ; Wen Lin, Hung. / Fatty acid methyl esters as a potential therapy against cerebral ischemia. In: OCL - Oilseeds and fats, crops and lipids. 2016 ; Vol. 23, No. 1.
@article{706d469886914888aac3895eee4d6f09,
title = "Fatty acid methyl esters as a potential therapy against cerebral ischemia",
abstract = "Saturated fatty acids have been traditionally thought to be detrimental in circulation. However, we describe the beneficial effects of palmitic and stearic acid methyl esters as it relates to neuroprotection and cerebral vasodilatory properties in global and focal cerebral ischemia. The methyl esterification of fatty acids is not prominent in nature. However, it seems to have biological activity related to neuroprotection/vasodilation. We will discuss the etiology of cerebral ischemia such as stroke and cardiac arrest in terms of current and future treatment modalitiesas it relates to fatty acid-based therapies. This review is based on the meeting presentation at the {"}The Journ{\'e}es Chevreul, Lipids & Brain III 2015{"} in Paris on 16-18 March, 2015.",
keywords = "Cerebral blood flow, Cerebral ischemia, Neuroprotection, Palmitic acid methyl ester, Protein arginine methyltransferase",
author = "Lee, {Reggie Hui Chao} and {Goyanes Vasquez}, {Juan Jose} and {Couto E Silva}, Alexandre and Klein, {Daniel D.} and Valido, {Stephen E.} and Chen, {Joseph A.} and Lerner, {Francesca M.} and Neumann, {Jake T.} and Wu, {Celeste Yin Chieh} and {Wen Lin}, Hung",
year = "2016",
month = "1",
day = "1",
doi = "10.1051/ocl/2015040",
language = "English (US)",
volume = "23",
journal = "OCL - Oilseeds and fats, crops and lipids",
issn = "2272-6977",
publisher = "EDP Sciences",
number = "1",

}

TY - JOUR

T1 - Fatty acid methyl esters as a potential therapy against cerebral ischemia

AU - Lee, Reggie Hui Chao

AU - Goyanes Vasquez, Juan Jose

AU - Couto E Silva, Alexandre

AU - Klein, Daniel D.

AU - Valido, Stephen E.

AU - Chen, Joseph A.

AU - Lerner, Francesca M.

AU - Neumann, Jake T.

AU - Wu, Celeste Yin Chieh

AU - Wen Lin, Hung

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Saturated fatty acids have been traditionally thought to be detrimental in circulation. However, we describe the beneficial effects of palmitic and stearic acid methyl esters as it relates to neuroprotection and cerebral vasodilatory properties in global and focal cerebral ischemia. The methyl esterification of fatty acids is not prominent in nature. However, it seems to have biological activity related to neuroprotection/vasodilation. We will discuss the etiology of cerebral ischemia such as stroke and cardiac arrest in terms of current and future treatment modalitiesas it relates to fatty acid-based therapies. This review is based on the meeting presentation at the "The Journées Chevreul, Lipids & Brain III 2015" in Paris on 16-18 March, 2015.

AB - Saturated fatty acids have been traditionally thought to be detrimental in circulation. However, we describe the beneficial effects of palmitic and stearic acid methyl esters as it relates to neuroprotection and cerebral vasodilatory properties in global and focal cerebral ischemia. The methyl esterification of fatty acids is not prominent in nature. However, it seems to have biological activity related to neuroprotection/vasodilation. We will discuss the etiology of cerebral ischemia such as stroke and cardiac arrest in terms of current and future treatment modalitiesas it relates to fatty acid-based therapies. This review is based on the meeting presentation at the "The Journées Chevreul, Lipids & Brain III 2015" in Paris on 16-18 March, 2015.

KW - Cerebral blood flow

KW - Cerebral ischemia

KW - Neuroprotection

KW - Palmitic acid methyl ester

KW - Protein arginine methyltransferase

UR - http://www.scopus.com/inward/record.url?scp=85000869891&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85000869891&partnerID=8YFLogxK

U2 - 10.1051/ocl/2015040

DO - 10.1051/ocl/2015040

M3 - Article

AN - SCOPUS:85000869891

VL - 23

JO - OCL - Oilseeds and fats, crops and lipids

JF - OCL - Oilseeds and fats, crops and lipids

SN - 2272-6977

IS - 1

M1 - D108

ER -