Fatigue in HIV-Infected People: A Three-Year Observational Study

Julie Barroso, Jane Leserman, James L. Harmon, Bradley Hammill, Brian W. Pence

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Context HIV-related fatigue remains the most frequent complaint of seropositive patients. Objectives To describe the natural course of fatigue in HIV infection, in a sample (n = 128) followed for a three-year period. Methods A longitudinal prospective design was used to determine what factors influenced changes in fatigue intensity and fatigue-related impairment of functioning in a community-dwelling sample of HIV-infected individuals. Participants were followed every six months for a three-year period. At each study visit, we collected data on a large number of physiological and psychosocial markers that have been shown to be related to fatigue in HIV-infected people. At three month intervals between study visits, we collected data on fatigue via mailed questionnaires. Results Fatigue in HIV infection is largely a result of stressful life events, and is closely tied to the anxiety and depression that accompany such events. Fatigue did not remit spontaneously over the course of the study, indicating the need for interventions to ameliorate this debilitating symptom. Conclusion Intervening to help people who are suffering from HIV-related fatigue to deal with stressful life events may help to ameliorate this debilitating symptom.

Original languageEnglish (US)
Pages (from-to)69-79
Number of pages11
JournalJournal of Pain and Symptom Management
Issue number1
StatePublished - Jul 1 2015
Externally publishedYes


  • HIV
  • fatigue
  • physiological factors
  • psychosocial factors

ASJC Scopus subject areas

  • Nursing(all)
  • Clinical Neurology
  • Anesthesiology and Pain Medicine


Dive into the research topics of 'Fatigue in HIV-Infected People: A Three-Year Observational Study'. Together they form a unique fingerprint.

Cite this