Fast phase-contrast cine MRI for assessing intracranial hemodynamics and cerebrospinal fluid dynamics

Naoki Ohno, Tosiaki Miyati, Tomohiro Noda, Noam Alperin, Takashi Hamaguchi, Masako Ohno, Tatsuhiko Matsushita, Mitsuhito Mase, Toshifumi Gabata, Satoshi Kobayashi

Research output: Contribution to journalArticle

Abstract

We propose fast phase-contrast cine magnetic resonance imaging (PC-cine MRI) to allow breath-hold acquisition, and we compared intracranial hemo- and hydrodynamic parameters obtained during breath holding between full inspiration and end expiration. On a 3.0 T MRI, using electrocardiogram (ECG)-synchronized fast PC-cine MRI with parallel imaging, rectangular field of view, and segmented k-space, we obtained velocity-mapped phase images at the mid-C2 level with different velocity encoding for transcranial blood flow and cerebrospinal-fluid (CSF) flow. Next, we calculated the peak-to-peak amplitudes of cerebral blood flow (ΔCBF), cerebral venous outflow, intracranial volume change, CSF pressure gradient (ΔPG), and intracranial compliance index. These parameters were compared between the proposed and conventional methods. Moreover, we compared these parameters between different utilized breath-hold maneuvers (inspiration, expiration, and free breathing). All parameters derived from the fast PC method agreed with those from the conventional method. The ΔPG was significantly higher during full inspiration breath holding than at the end of expiration and during free breathing. The proposed fast PC-cine MRI reduced scan time (within 30 s) with good agreement with conventional methods. The use of this method also makes it possible to assess the effects of respiration on intracranial hemo- and hydrodynamics.

Original languageEnglish (US)
Article number241
JournalDiagnostics
Volume10
Issue number4
DOIs
StatePublished - Apr 2020

Keywords

  • Cerebrospinal fluid hydrodynamics
  • Intracranial hemodynamics
  • Phase-contrast
  • Respiration

ASJC Scopus subject areas

  • Clinical Biochemistry

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    Ohno, N., Miyati, T., Noda, T., Alperin, N., Hamaguchi, T., Ohno, M., Matsushita, T., Mase, M., Gabata, T., & Kobayashi, S. (2020). Fast phase-contrast cine MRI for assessing intracranial hemodynamics and cerebrospinal fluid dynamics. Diagnostics, 10(4), [241]. https://doi.org/10.3390/diagnostics10040241