Fast feedback regulation of acth by cortisol

K. Ranga Rama Krishnan; James C. Ritchie; Ananth N. Manepalli; William Saunders; Wei Li Shun Wei Li; Sanjeev Venkataraman; Charles B. Nemeroff; Bernard J. Carroll

doi:10.1016/0278-5846(91)90027-X

Fast feedback regulation of acth by cortisol

K. Ranga Rama Krishnan, James C. Ritchie, Ananth N. Manepalli, William Saunders, Wei Li Shun Wei Li, Sanjeev Venkataraman, Charles B. Nemeroff, Bernard J. Carroll

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

1. Fast feedback regulation of ACTH by cortisol has not been well studied in humans. The authors studied the existence and characteristics of fast feedback regulation in normal humans. 2. Hydrocortisone hemisuccinate was infused at two different rates: 6 mg/hour and 12 mg/hour for two hours. 3. The studies did not demonstrate the existence of fast feedback regulation of basal ACTH concentration by cortisol in man. Further, the response was variable and the rate sensitive character was difficult to demonstrate.

Original language	English (US)
Pages (from-to)	523-529
Number of pages	7
Journal	Progress in Neuropsychopharmacology and Biological Psychiatry
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/0278-5846(91)90027-X
State	Published - 1991
Externally published	Yes

Keywords

adrenocortlcotropin
cortisol
fast feedback
humans

ASJC Scopus subject areas

Biological Psychiatry
Pharmacology

Access to Document

10.1016/0278-5846(91)90027-X

Fingerprint Dive into the research topics of 'Fast feedback regulation of acth by cortisol'. Together they form a unique fingerprint.

Cite this

Fast feedback regulation of acth by cortisol. / Rama Krishnan, K. Ranga; Ritchie, James C.; Manepalli, Ananth N.; Saunders, William; Shun Wei Li, Wei Li; Venkataraman, Sanjeev; Nemeroff, Charles B.; Carroll, Bernard J.

In: Progress in Neuropsychopharmacology and Biological Psychiatry, Vol. 15, No. 4, 1991, p. 523-529.

Research output: Contribution to journal › Article › peer-review

@article{c90922e2e8a74edeb27196fe37a80e25,

title = "Fast feedback regulation of acth by cortisol",

abstract = "1. Fast feedback regulation of ACTH by cortisol has not been well studied in humans. The authors studied the existence and characteristics of fast feedback regulation in normal humans. 2. Hydrocortisone hemisuccinate was infused at two different rates: 6 mg/hour and 12 mg/hour for two hours. 3. The studies did not demonstrate the existence of fast feedback regulation of basal ACTH concentration by cortisol in man. Further, the response was variable and the rate sensitive character was difficult to demonstrate.",

keywords = "adrenocortlcotropin, cortisol, fast feedback, humans",

author = "{Rama Krishnan}, {K. Ranga} and Ritchie, {James C.} and Manepalli, {Ananth N.} and William Saunders and {Shun Wei Li}, {Wei Li} and Sanjeev Venkataraman and Nemeroff, {Charles B.} and Carroll, {Bernard J.}",

year = "1991",

doi = "10.1016/0278-5846(91)90027-X",

language = "English (US)",

volume = "15",

pages = "523--529",

journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",

issn = "0278-5846",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Fast feedback regulation of acth by cortisol

AU - Rama Krishnan, K. Ranga

AU - Ritchie, James C.

AU - Manepalli, Ananth N.

AU - Saunders, William

AU - Shun Wei Li, Wei Li

AU - Venkataraman, Sanjeev

AU - Nemeroff, Charles B.

AU - Carroll, Bernard J.

PY - 1991

Y1 - 1991

N2 - 1. Fast feedback regulation of ACTH by cortisol has not been well studied in humans. The authors studied the existence and characteristics of fast feedback regulation in normal humans. 2. Hydrocortisone hemisuccinate was infused at two different rates: 6 mg/hour and 12 mg/hour for two hours. 3. The studies did not demonstrate the existence of fast feedback regulation of basal ACTH concentration by cortisol in man. Further, the response was variable and the rate sensitive character was difficult to demonstrate.

AB - 1. Fast feedback regulation of ACTH by cortisol has not been well studied in humans. The authors studied the existence and characteristics of fast feedback regulation in normal humans. 2. Hydrocortisone hemisuccinate was infused at two different rates: 6 mg/hour and 12 mg/hour for two hours. 3. The studies did not demonstrate the existence of fast feedback regulation of basal ACTH concentration by cortisol in man. Further, the response was variable and the rate sensitive character was difficult to demonstrate.

KW - adrenocortlcotropin

KW - cortisol

KW - fast feedback

KW - humans

UR - http://www.scopus.com/inward/record.url?scp=0025808086&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025808086&partnerID=8YFLogxK

U2 - 10.1016/0278-5846(91)90027-X

DO - 10.1016/0278-5846(91)90027-X

M3 - Article

C2 - 1661015

AN - SCOPUS:0025808086

VL - 15

SP - 523

EP - 529

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

IS - 4

ER -