Fast feedback regulation of acth by cortisol

K. Ranga Rama Krishnan; James C. Ritchie; Ananth N. Manepalli; William Saunders; Wei Li Shun Wei Li; Sanjeev Venkataraman; Charles B. Nemeroff; Bernard J. Carroll

doi:10.1016/0278-5846(91)90027-X

Fast feedback regulation of acth by cortisol

K. Ranga Rama Krishnan, James C. Ritchie, Ananth N. Manepalli, William Saunders, Wei Li Shun Wei Li, Sanjeev Venkataraman, Charles B. Nemeroff, Bernard J. Carroll

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

1. Fast feedback regulation of ACTH by cortisol has not been well studied in humans. The authors studied the existence and characteristics of fast feedback regulation in normal humans. 2. Hydrocortisone hemisuccinate was infused at two different rates: 6 mg/hour and 12 mg/hour for two hours. 3. The studies did not demonstrate the existence of fast feedback regulation of basal ACTH concentration by cortisol in man. Further, the response was variable and the rate sensitive character was difficult to demonstrate.

Original language	English (US)
Pages (from-to)	523-529
Number of pages	7
Journal	Progress in Neuropsychopharmacology and Biological Psychiatry
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/0278-5846(91)90027-X
State	Published - 1991
Externally published	Yes

Keywords

adrenocortlcotropin
cortisol
fast feedback
humans

ASJC Scopus subject areas

Biological Psychiatry
Pharmacology

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10.1016/0278-5846(91)90027-X

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Fast feedback regulation of acth by cortisol. / Rama Krishnan, K. Ranga; Ritchie, James C.; Manepalli, Ananth N.; Saunders, William; Shun Wei Li, Wei Li; Venkataraman, Sanjeev; Nemeroff, Charles B.; Carroll, Bernard J.

In: Progress in Neuropsychopharmacology and Biological Psychiatry, Vol. 15, No. 4, 1991, p. 523-529.

Research output: Contribution to journal › Article › peer-review

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AU - Shun Wei Li, Wei Li

AU - Venkataraman, Sanjeev

AU - Nemeroff, Charles B.

AU - Carroll, Bernard J.

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N2 - 1. Fast feedback regulation of ACTH by cortisol has not been well studied in humans. The authors studied the existence and characteristics of fast feedback regulation in normal humans. 2. Hydrocortisone hemisuccinate was infused at two different rates: 6 mg/hour and 12 mg/hour for two hours. 3. The studies did not demonstrate the existence of fast feedback regulation of basal ACTH concentration by cortisol in man. Further, the response was variable and the rate sensitive character was difficult to demonstrate.

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KW - cortisol

KW - fast feedback

KW - humans

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Fast feedback regulation of acth by cortisol

Abstract

Keywords

ASJC Scopus subject areas

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