Fast feedback regulation of acth by cortisol

K. Ranga Rama Krishnan, James C. Ritchie, Ananth N. Manepalli, William Saunders, Wei Li Shun Wei Li, Sanjeev Venkataraman, Charles B. Nemeroff, Bernard J. Carroll

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


1. Fast feedback regulation of ACTH by cortisol has not been well studied in humans. The authors studied the existence and characteristics of fast feedback regulation in normal humans. 2. Hydrocortisone hemisuccinate was infused at two different rates: 6 mg/hour and 12 mg/hour for two hours. 3. The studies did not demonstrate the existence of fast feedback regulation of basal ACTH concentration by cortisol in man. Further, the response was variable and the rate sensitive character was difficult to demonstrate.

Original languageEnglish (US)
Pages (from-to)523-529
Number of pages7
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Issue number4
StatePublished - 1991
Externally publishedYes


  • adrenocortlcotropin
  • cortisol
  • fast feedback
  • humans

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology


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