Fast feedback regulation of acth by cortisol

K. Ranga Rama Krishnan, James C. Ritchie, Ananth N. Manepalli, William Saunders, Wei Li Shun Wei Li, Sanjeev Venkataraman, Charles Nemeroff, Bernard J. Carroll

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

1. Fast feedback regulation of ACTH by cortisol has not been well studied in humans. The authors studied the existence and characteristics of fast feedback regulation in normal humans. 2. Hydrocortisone hemisuccinate was infused at two different rates: 6 mg/hour and 12 mg/hour for two hours. 3. The studies did not demonstrate the existence of fast feedback regulation of basal ACTH concentration by cortisol in man. Further, the response was variable and the rate sensitive character was difficult to demonstrate.

Original languageEnglish
Pages (from-to)523-529
Number of pages7
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume15
Issue number4
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

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Keywords

  • adrenocortlcotropin
  • cortisol
  • fast feedback
  • humans

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Rama Krishnan, K. R., Ritchie, J. C., Manepalli, A. N., Saunders, W., Shun Wei Li, W. L., Venkataraman, S., Nemeroff, C., & Carroll, B. J. (1991). Fast feedback regulation of acth by cortisol. Progress in Neuropsychopharmacology and Biological Psychiatry, 15(4), 523-529. https://doi.org/10.1016/0278-5846(91)90027-X