Abstract
1. Fast feedback regulation of ACTH by cortisol has not been well studied in humans. The authors studied the existence and characteristics of fast feedback regulation in normal humans. 2. Hydrocortisone hemisuccinate was infused at two different rates: 6 mg/hour and 12 mg/hour for two hours. 3. The studies did not demonstrate the existence of fast feedback regulation of basal ACTH concentration by cortisol in man. Further, the response was variable and the rate sensitive character was difficult to demonstrate.
| Original language | English |
|---|---|
| Pages (from-to) | 523-529 |
| Number of pages | 7 |
| Journal | Progress in Neuropsychopharmacology and Biological Psychiatry |
| Volume | 15 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 1991 |
| Externally published | Yes |
Fingerprint
Keywords
- adrenocortlcotropin
- cortisol
- fast feedback
- humans
ASJC Scopus subject areas
- Biological Psychiatry
- Pharmacology
Cite this
Fast feedback regulation of acth by cortisol. / Rama Krishnan, K. Ranga; Ritchie, James C.; Manepalli, Ananth N.; Saunders, William; Shun Wei Li, Wei Li; Venkataraman, Sanjeev; Nemeroff, Charles; Carroll, Bernard J.
In: Progress in Neuropsychopharmacology and Biological Psychiatry, Vol. 15, No. 4, 01.01.1991, p. 523-529.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fast feedback regulation of acth by cortisol
AU - Rama Krishnan, K. Ranga
AU - Ritchie, James C.
AU - Manepalli, Ananth N.
AU - Saunders, William
AU - Shun Wei Li, Wei Li
AU - Venkataraman, Sanjeev
AU - Nemeroff, Charles
AU - Carroll, Bernard J.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - 1. Fast feedback regulation of ACTH by cortisol has not been well studied in humans. The authors studied the existence and characteristics of fast feedback regulation in normal humans. 2. Hydrocortisone hemisuccinate was infused at two different rates: 6 mg/hour and 12 mg/hour for two hours. 3. The studies did not demonstrate the existence of fast feedback regulation of basal ACTH concentration by cortisol in man. Further, the response was variable and the rate sensitive character was difficult to demonstrate.
AB - 1. Fast feedback regulation of ACTH by cortisol has not been well studied in humans. The authors studied the existence and characteristics of fast feedback regulation in normal humans. 2. Hydrocortisone hemisuccinate was infused at two different rates: 6 mg/hour and 12 mg/hour for two hours. 3. The studies did not demonstrate the existence of fast feedback regulation of basal ACTH concentration by cortisol in man. Further, the response was variable and the rate sensitive character was difficult to demonstrate.
KW - adrenocortlcotropin
KW - cortisol
KW - fast feedback
KW - humans
UR - http://www.scopus.com/inward/record.url?scp=0025808086&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025808086&partnerID=8YFLogxK
U2 - 10.1016/0278-5846(91)90027-X
DO - 10.1016/0278-5846(91)90027-X
M3 - Article
C2 - 1661015
AN - SCOPUS:0025808086
VL - 15
SP - 523
EP - 529
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
IS - 4
ER -