Fast feedback regulation of acth by cortisol

K. Ranga Rama Krishnan; James C. Ritchie; Ananth N. Manepalli; William Saunders; Wei Li Shun Wei Li; Sanjeev Venkataraman; Charles Nemeroff; Bernard J. Carroll

doi:10.1016/0278-5846(91)90027-X

Fast feedback regulation of acth by cortisol

K. Ranga Rama Krishnan, James C. Ritchie, Ananth N. Manepalli, William Saunders, Wei Li Shun Wei Li, Sanjeev Venkataraman, Charles Nemeroff, Bernard J. Carroll

Research output: Contribution to journal › Article

11 Scopus citations

Abstract

1. Fast feedback regulation of ACTH by cortisol has not been well studied in humans. The authors studied the existence and characteristics of fast feedback regulation in normal humans. 2. Hydrocortisone hemisuccinate was infused at two different rates: 6 mg/hour and 12 mg/hour for two hours. 3. The studies did not demonstrate the existence of fast feedback regulation of basal ACTH concentration by cortisol in man. Further, the response was variable and the rate sensitive character was difficult to demonstrate.

Original language	English
Pages (from-to)	523-529
Number of pages	7
Journal	Progress in Neuropsychopharmacology and Biological Psychiatry
Volume	15
Issue number	4
DOIs	https://doi.org/10.1016/0278-5846(91)90027-X
State	Published - Jan 1 1991
Externally published	Yes

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Keywords

adrenocortlcotropin
cortisol
fast feedback
humans

ASJC Scopus subject areas

Biological Psychiatry
Pharmacology

Cite this

Rama Krishnan, K. R., Ritchie, J. C., Manepalli, A. N., Saunders, W., Shun Wei Li, W. L., Venkataraman, S., Nemeroff, C., & Carroll, B. J. (1991). Fast feedback regulation of acth by cortisol. Progress in Neuropsychopharmacology and Biological Psychiatry, 15(4), 523-529. https://doi.org/10.1016/0278-5846(91)90027-X

Fast feedback regulation of acth by cortisol. / Rama Krishnan, K. Ranga; Ritchie, James C.; Manepalli, Ananth N.; Saunders, William; Shun Wei Li, Wei Li; Venkataraman, Sanjeev; Nemeroff, Charles; Carroll, Bernard J.

In: Progress in Neuropsychopharmacology and Biological Psychiatry, Vol. 15, No. 4, 01.01.1991, p. 523-529.

Research output: Contribution to journal › Article

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10.1016/0278-5846(91)90027-X