Fast axonal transport in early experimental disc edema

R. L. Radius, Douglas Anderson

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Previous work has documented impairment of slow axonal transport in papilledema, but the abnormalities in rapid transport were less certain. Therefore fast axonal transport was studied in 19 primate eyes subjected to ocular hypotony for 6 to 72 hr following surgical fistulization of the anterior chamber. Mild, irregular alterations in fast axonal transport were detected only after nerve head swelling was apparent. These changes in fast transport mechanisms in cases of nerve head edema occur after, and may be secondary to, impaired slow axoplasmic flow and the resultant axonal swelling. Furthermore, since prolonged complete interruption of axonal transport is theoretically inconsistent with the continued normal neuron function characteristic of papilledema and, moreover, since previous data shows a 'slowdown' rather than complete blockade of axonal transport in papilledema, it is likely that in eyes with papilledema there does not exist a complete block of axonal transport in papilledema, it is likely that in eyes with papilledema there does not exist a complete block of axonal transport. Therefore we hypothesize that the swelling results when slow axoplasmic flow is locally slowed down but not totally stopped, with the axon distention producing secondary mild, irregular changes in fast axonal transport.

Original languageEnglish
Pages (from-to)158-168
Number of pages11
JournalInvestigative Ophthalmology and Visual Science
Volume19
Issue number2
StatePublished - Jan 1 1980

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Axonal Transport
Edema
Papilledema
Ocular Hypotension
Anterior Chamber
Primates
Axons
Neurons

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Fast axonal transport in early experimental disc edema. / Radius, R. L.; Anderson, Douglas.

In: Investigative Ophthalmology and Visual Science, Vol. 19, No. 2, 01.01.1980, p. 158-168.

Research output: Contribution to journalArticle

Radius, R. L. ; Anderson, Douglas. / Fast axonal transport in early experimental disc edema. In: Investigative Ophthalmology and Visual Science. 1980 ; Vol. 19, No. 2. pp. 158-168.
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