Fasciclin III as a synaptic target recognition molecule in Drosophila

Akira Chiba, P. Snow, H. Keshishian, Y. Hotta

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Fasciclin III, a cell adhesion molecule of the immunoglobulin superfamily, is expressed by motor neuron RP3 and its synaptic targets (muscle cells 6 and 7) during embryonic neuromuscular development of Drosophila. We report here that RP3 often incorrectly innervates neighbouring non-target muscle cells when these cells misexpress fasciclin III, but still innervates normal targets in the fasciclin III null mutant. Fasciclin III manipulations do not influence target selections by other motor neurons, including fasciclin III-expressing RP1. We propose that fasciclin III acts as a synaptic target recognition molecule for motor neuron RP3, and also that its absence can be compensated for by other molecule(s).

Original languageEnglish
Pages (from-to)166-168
Number of pages3
JournalNature
Volume374
Issue number6518
StatePublished - Jan 1 1995
Externally publishedYes

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Motor Neurons
Drosophila
Muscle Cells
Cell Adhesion Molecules
Embryonic Development
Immunoglobulins

ASJC Scopus subject areas

  • General

Cite this

Chiba, A., Snow, P., Keshishian, H., & Hotta, Y. (1995). Fasciclin III as a synaptic target recognition molecule in Drosophila. Nature, 374(6518), 166-168.

Fasciclin III as a synaptic target recognition molecule in Drosophila. / Chiba, Akira; Snow, P.; Keshishian, H.; Hotta, Y.

In: Nature, Vol. 374, No. 6518, 01.01.1995, p. 166-168.

Research output: Contribution to journalArticle

Chiba, A, Snow, P, Keshishian, H & Hotta, Y 1995, 'Fasciclin III as a synaptic target recognition molecule in Drosophila', Nature, vol. 374, no. 6518, pp. 166-168.
Chiba A, Snow P, Keshishian H, Hotta Y. Fasciclin III as a synaptic target recognition molecule in Drosophila. Nature. 1995 Jan 1;374(6518):166-168.
Chiba, Akira ; Snow, P. ; Keshishian, H. ; Hotta, Y. / Fasciclin III as a synaptic target recognition molecule in Drosophila. In: Nature. 1995 ; Vol. 374, No. 6518. pp. 166-168.
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