Fanconi anemia pathway as a prospective target for cancer intervention

Wenjun Liu, Anna Palovcak, Fang Li, Alyan Zafar, Fenghua Yuan, Yanbin Zhang

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and congenital abnormalities, FA is associated with chromosomal abnormality and genomic instability, and thus represents a genetic vulnerability for cancer predisposition. The cancer relevance of the FA pathway is further established with the pervasive occurrence of FA gene alterations in somatic cancers and observations of FA pathway activation-associated chemotherapy resistance. In this article we describe the role of the FA pathway in canonical interstrand crosslink (ICL) repair and possible contributions of FA gene alterations to cancer development. We also discuss the perspectives and potential of targeting the FA pathway for cancer intervention.

Original languageEnglish (US)
Article number39
JournalCell and Bioscience
Volume10
Issue number1
DOIs
StatePublished - Mar 16 2020

Keywords

  • Cancer intervention
  • DNA repair
  • Fanconi anemia
  • Tumorigenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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