Family history of venous thromboembolism and identifying factor v leiden carriers during pregnancy

Amanda L. Horton, Valerija Momirova, Donna Dizon-Townson, Katharine Wenstrom, George Wendel, Philip Samuels, Baha Sibai, Catherine Y. Spong, Margaret Cotroneo, Yoram Sorokin, Menachem Miodovnik, Mary J. O'Sullivan, Deborah Conway, Ronald J. Wapner

Research output: Contribution to journalArticle

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Abstract

Objective: To estimate whether there is a correlation between family history of venous thromboembolism and factor V Leiden mutation carriage in gravid women without a personal history of venous thromboembolism. Methods: This is a secondary analysis of a prospective observational study of the frequency of pregnancy-related thromboembolic events among carriers of the factor V Leiden mutation. Family history of venous thromboembolism in either first-or second-degree relatives was self-reported. Sensitivity, specificity, and positive and negative predictive values of family history to predict factor V Leiden mutation carrier status were calculated. Results: Women without a personal venous thromboembolism history and with available DNA were included (n=5,168). One hundred forty women (2.7% [95% confidence interval (CI) 2.3-3.2%]) were factor V Leiden mutation-positive. Four hundred twelve women (8.0% [95% CI 7.3-8.7%]) reported a family history of venous thromboembolism. Women with a positive family history were twofold more likely to be factor V Leiden mutation carriers than those with a negative family history (23 of 412 [5.6%] compared with 117 of 4,756 [2.5%], P<.001). The sensitivity, specificity, and positive predictive value of a family history of a first-or second-degree relative for identifying factor V Leiden carriers were 16.4% (95% CI 10.7-23.6%), 92.3% (95% CI 91.5-93.0%), and 5.6% (95% CI 3.6-8.3%), respectively. Conclusion: Although a family history of venous thromboembolism is associated with factor V Leiden mutation in thrombosis-free gravid women, the sensitivity and positive predictive values are too low to recommend screening women for the factor V Leiden mutation based solely on a family history.

Original languageEnglish
Pages (from-to)521-525
Number of pages5
JournalObstetrics and Gynecology
Volume115
Issue number3
DOIs
StatePublished - Mar 1 2010

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Venous Thromboembolism
Pregnancy
Mutation
Confidence Intervals
Sensitivity and Specificity
factor V Leiden
Observational Studies
Thrombosis
Prospective Studies
DNA

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Horton, A. L., Momirova, V., Dizon-Townson, D., Wenstrom, K., Wendel, G., Samuels, P., ... Wapner, R. J. (2010). Family history of venous thromboembolism and identifying factor v leiden carriers during pregnancy. Obstetrics and Gynecology, 115(3), 521-525. https://doi.org/10.1097/AOG.0b013e3181d018a8

Family history of venous thromboembolism and identifying factor v leiden carriers during pregnancy. / Horton, Amanda L.; Momirova, Valerija; Dizon-Townson, Donna; Wenstrom, Katharine; Wendel, George; Samuels, Philip; Sibai, Baha; Spong, Catherine Y.; Cotroneo, Margaret; Sorokin, Yoram; Miodovnik, Menachem; O'Sullivan, Mary J.; Conway, Deborah; Wapner, Ronald J.

In: Obstetrics and Gynecology, Vol. 115, No. 3, 01.03.2010, p. 521-525.

Research output: Contribution to journalArticle

Horton, AL, Momirova, V, Dizon-Townson, D, Wenstrom, K, Wendel, G, Samuels, P, Sibai, B, Spong, CY, Cotroneo, M, Sorokin, Y, Miodovnik, M, O'Sullivan, MJ, Conway, D & Wapner, RJ 2010, 'Family history of venous thromboembolism and identifying factor v leiden carriers during pregnancy', Obstetrics and Gynecology, vol. 115, no. 3, pp. 521-525. https://doi.org/10.1097/AOG.0b013e3181d018a8
Horton, Amanda L. ; Momirova, Valerija ; Dizon-Townson, Donna ; Wenstrom, Katharine ; Wendel, George ; Samuels, Philip ; Sibai, Baha ; Spong, Catherine Y. ; Cotroneo, Margaret ; Sorokin, Yoram ; Miodovnik, Menachem ; O'Sullivan, Mary J. ; Conway, Deborah ; Wapner, Ronald J. / Family history of venous thromboembolism and identifying factor v leiden carriers during pregnancy. In: Obstetrics and Gynecology. 2010 ; Vol. 115, No. 3. pp. 521-525.
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abstract = "Objective: To estimate whether there is a correlation between family history of venous thromboembolism and factor V Leiden mutation carriage in gravid women without a personal history of venous thromboembolism. Methods: This is a secondary analysis of a prospective observational study of the frequency of pregnancy-related thromboembolic events among carriers of the factor V Leiden mutation. Family history of venous thromboembolism in either first-or second-degree relatives was self-reported. Sensitivity, specificity, and positive and negative predictive values of family history to predict factor V Leiden mutation carrier status were calculated. Results: Women without a personal venous thromboembolism history and with available DNA were included (n=5,168). One hundred forty women (2.7{\%} [95{\%} confidence interval (CI) 2.3-3.2{\%}]) were factor V Leiden mutation-positive. Four hundred twelve women (8.0{\%} [95{\%} CI 7.3-8.7{\%}]) reported a family history of venous thromboembolism. Women with a positive family history were twofold more likely to be factor V Leiden mutation carriers than those with a negative family history (23 of 412 [5.6{\%}] compared with 117 of 4,756 [2.5{\%}], P<.001). The sensitivity, specificity, and positive predictive value of a family history of a first-or second-degree relative for identifying factor V Leiden carriers were 16.4{\%} (95{\%} CI 10.7-23.6{\%}), 92.3{\%} (95{\%} CI 91.5-93.0{\%}), and 5.6{\%} (95{\%} CI 3.6-8.3{\%}), respectively. Conclusion: Although a family history of venous thromboembolism is associated with factor V Leiden mutation in thrombosis-free gravid women, the sensitivity and positive predictive values are too low to recommend screening women for the factor V Leiden mutation based solely on a family history.",
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AU - Wendel, George

AU - Samuels, Philip

AU - Sibai, Baha

AU - Spong, Catherine Y.

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AU - Sorokin, Yoram

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