Abstract
In humans, a first-degree family history of dementia (FH) is a well-documented risk factor for Alzheimer's disease (AD); however, the influence of FH on cognition across the lifespan is poorly understood. To address this issue, we developed an internet-based paired-associates learning (PAL) task and tested 59,571 participants between the ages of 18-85. FH was associated with lower PAL performance in both sexes under 65 years old. Modifiers of this effect of FH on PAL performance included age, sex, education, and diabetes. The Apolipoprotein E ε4 allele was also associated with lower PAL scores in FH positive individuals. Here we show, FH is associated with reduced PAL performance four decades before the typical onset of AD; additionally, several heritable and non-heritable modifiers of this effect were identified.
| Original language | English (US) |
|---|---|
| Journal | eLife |
| Volume | 8 |
| DOIs | |
| State | Published - Jun 18 2019 |
| Externally published | Yes |
Fingerprint
Keywords
- Alzheimer's Disease
- Apolipoprotein E (APOE)
- dementia
- family history
- human
- human biology
- internet-based
- medicine
- neuroscience
- paired-associates learning
ASJC Scopus subject areas
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
Cite this
Family history of Alzheimer's disease alters cognition and is modified by medical and genetic factors. / Talboom, Joshua S.; Håberg, Asta; De Both, Matthew D.; Naymik, Marcus A.; Schrauwen, Isabelle; Lewis, Candace R.; Bertinelli, Stacy F.; Hammersland, Callie; Fritz, Mason A.; Myers, Amanda J.; Hay, Meredith; Barnes, Carol A.; Glisky, Elizabeth; Ryan, Lee; Huentelman, Matthew J.
In: eLife, Vol. 8, 18.06.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Family history of Alzheimer's disease alters cognition and is modified by medical and genetic factors
AU - Talboom, Joshua S.
AU - Håberg, Asta
AU - De Both, Matthew D.
AU - Naymik, Marcus A.
AU - Schrauwen, Isabelle
AU - Lewis, Candace R.
AU - Bertinelli, Stacy F.
AU - Hammersland, Callie
AU - Fritz, Mason A.
AU - Myers, Amanda J.
AU - Hay, Meredith
AU - Barnes, Carol A.
AU - Glisky, Elizabeth
AU - Ryan, Lee
AU - Huentelman, Matthew J.
PY - 2019/6/18
Y1 - 2019/6/18
N2 - In humans, a first-degree family history of dementia (FH) is a well-documented risk factor for Alzheimer's disease (AD); however, the influence of FH on cognition across the lifespan is poorly understood. To address this issue, we developed an internet-based paired-associates learning (PAL) task and tested 59,571 participants between the ages of 18-85. FH was associated with lower PAL performance in both sexes under 65 years old. Modifiers of this effect of FH on PAL performance included age, sex, education, and diabetes. The Apolipoprotein E ε4 allele was also associated with lower PAL scores in FH positive individuals. Here we show, FH is associated with reduced PAL performance four decades before the typical onset of AD; additionally, several heritable and non-heritable modifiers of this effect were identified.
AB - In humans, a first-degree family history of dementia (FH) is a well-documented risk factor for Alzheimer's disease (AD); however, the influence of FH on cognition across the lifespan is poorly understood. To address this issue, we developed an internet-based paired-associates learning (PAL) task and tested 59,571 participants between the ages of 18-85. FH was associated with lower PAL performance in both sexes under 65 years old. Modifiers of this effect of FH on PAL performance included age, sex, education, and diabetes. The Apolipoprotein E ε4 allele was also associated with lower PAL scores in FH positive individuals. Here we show, FH is associated with reduced PAL performance four decades before the typical onset of AD; additionally, several heritable and non-heritable modifiers of this effect were identified.
KW - Alzheimer's Disease
KW - Apolipoprotein E (APOE)
KW - dementia
KW - family history
KW - human
KW - human biology
KW - internet-based
KW - medicine
KW - neuroscience
KW - paired-associates learning
UR - http://www.scopus.com/inward/record.url?scp=85069297486&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85069297486&partnerID=8YFLogxK
U2 - 10.7554/eLife.46179
DO - 10.7554/eLife.46179
M3 - Article
C2 - 31210642
AN - SCOPUS:85069297486
VL - 8
JO - eLife
JF - eLife
SN - 2050-084X
ER -