Family history of Alzheimer's disease alters cognition and is modified by medical and genetic factors

Joshua S. Talboom; Asta Håberg; Matthew D. De Both; Marcus A. Naymik; Isabelle Schrauwen; Candace R. Lewis; Stacy F. Bertinelli; Callie Hammersland; Mason A. Fritz; Amanda J. Myers; Meredith Hay; Carol A. Barnes; Elizabeth Glisky; Lee Ryan; Matthew J. Huentelman

doi:10.7554/eLife.46179

Family history of Alzheimer's disease alters cognition and is modified by medical and genetic factors

Joshua S. Talboom, Asta Håberg, Matthew D. De Both, Marcus A. Naymik, Isabelle Schrauwen, Candace R. Lewis, Stacy F. Bertinelli, Callie Hammersland, Mason A. Fritz, Amanda J. Myers, Meredith Hay, Carol A. Barnes, Elizabeth Glisky, Lee Ryan, Matthew J. Huentelman

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

In humans, a first-degree family history of dementia (FH) is a well-documented risk factor for Alzheimer's disease (AD); however, the influence of FH on cognition across the lifespan is poorly understood. To address this issue, we developed an internet-based paired-associates learning (PAL) task and tested 59,571 participants between the ages of 18-85. FH was associated with lower PAL performance in both sexes under 65 years old. Modifiers of this effect of FH on PAL performance included age, sex, education, and diabetes. The Apolipoprotein E ε4 allele was also associated with lower PAL scores in FH positive individuals. Here we show, FH is associated with reduced PAL performance four decades before the typical onset of AD; additionally, several heritable and non-heritable modifiers of this effect were identified.

Original language	English (US)
Journal	eLife
Volume	8
DOIs	https://doi.org/10.7554/eLife.46179
State	Published - Jun 18 2019
Externally published	Yes

Keywords

Alzheimer's Disease
Apolipoprotein E (APOE)
dementia
family history
human
human biology
internet-based
medicine
neuroscience
paired-associates learning

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

Access to Document

10.7554/eLife.46179

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Cite this

Talboom, J. S., Håberg, A., De Both, M. D., Naymik, M. A., Schrauwen, I., Lewis, C. R., Bertinelli, S. F., Hammersland, C., Fritz, M. A., Myers, A. J., Hay, M., Barnes, C. A., Glisky, E., Ryan, L., & Huentelman, M. J. (2019). Family history of Alzheimer's disease alters cognition and is modified by medical and genetic factors. eLife, 8. https://doi.org/10.7554/eLife.46179

Family history of Alzheimer's disease alters cognition and is modified by medical and genetic factors. / Talboom, Joshua S.; Håberg, Asta; De Both, Matthew D.; Naymik, Marcus A.; Schrauwen, Isabelle; Lewis, Candace R.; Bertinelli, Stacy F.; Hammersland, Callie; Fritz, Mason A.; Myers, Amanda J.; Hay, Meredith; Barnes, Carol A.; Glisky, Elizabeth; Ryan, Lee; Huentelman, Matthew J.

In: eLife, Vol. 8, 18.06.2019.

Research output: Contribution to journal › Article

Talboom, Joshua S. ; Håberg, Asta ; De Both, Matthew D. ; Naymik, Marcus A. ; Schrauwen, Isabelle ; Lewis, Candace R. ; Bertinelli, Stacy F. ; Hammersland, Callie ; Fritz, Mason A. ; Myers, Amanda J. ; Hay, Meredith ; Barnes, Carol A. ; Glisky, Elizabeth ; Ryan, Lee ; Huentelman, Matthew J. / Family history of Alzheimer's disease alters cognition and is modified by medical and genetic factors. In: eLife. 2019 ; Vol. 8.

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