Family-based case-control study of MAOA and MAOB polymorphisms in Parkinson disease

Sun J. Kang, Wlliam K. Scott, Yi Ju Li, Michael A. Hause, Joelle M. van der Walt, Kenichiro Fujiwara, Gregory M. Mayhew, Sandra G. West, Jeffrey M. Vance, Eden R. Martin

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Monoamine oxidase (MAO) is an enzyme regulating metabolism of neurotransmitters such as dopamine. Two distinct forms of enzyme, encoded by genes MAOA and MAOB located on the X chromosome, have been considered as possible factors in the pathogenesis of Parkinson disease (PD). Previous association studies of PD and MAO genes reported inconsistent results. In this study, we used a large family-based data set to test associations between MAO genes and a risk of PD. The data set includes 298 female discordant sibpairs and 348 male discordant sibpairs. For this study, all subjects analyzed were white and families with known parkin mutations were removed. We analyzed 15 single nucleotide polyrnorphisms (SNPs) and a dinucleotide repeat marker in the MAO genes. Association was found with the intron 13 SNP of MAOB in the female subset (P = 0.02). No significant association was found in the male subset. Our results add to the evidence of involvement of MAOB in PD and suggest that the effect may be stronger in women.

Original languageEnglish (US)
Pages (from-to)2175-2180
Number of pages6
JournalMovement Disorders
Volume21
Issue number12
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

Keywords

  • Family-based association
  • MAOA
  • MAOD
  • PD

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Kang, S. J., Scott, W. K., Li, Y. J., Hause, M. A., van der Walt, J. M., Fujiwara, K., Mayhew, G. M., West, S. G., Vance, J. M., & Martin, E. R. (2006). Family-based case-control study of MAOA and MAOB polymorphisms in Parkinson disease. Movement Disorders, 21(12), 2175-2180. https://doi.org/10.1002/mds.21151