Familial testicular cancer and second primary cancers in testicular cancer patients by histological type

C. Dong, I. Lönnstedt, K. Hemminki

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

The Swedish Family-Cancer Database was used to assess familial cancer risks in first-degree relatives and the risks of second primary cancers in testicular cancer patients by the histological type of their testicular cancers. Standardised incidence ratios (SIRs) were employed to estimate cancer risks. Among 4650 patients, 1.3% were familial testicular cancer. Seminomas showed a 10 years later median age of onset than teratomas (30 versus 40 years). The familial risks of testicular cancer were 3.8 for fathers, 8.3 for brothers and 3.9 for sons; they were similar for the two histologies. The fraternal risks were elevated 2- to 2.8-fold for pure histologies compared with the mixed histologies. Significantly increased risks for subsequent cancers were observed in the stomach, pancreas, testis, kidney, bladder, thyroid and connective and lymphatic tissues in the patients. Our data support the contention that genetic predisposition is one of the major contributors to familial and multiple testicular cancers.

Original languageEnglish (US)
Pages (from-to)1878-1885
Number of pages8
JournalEuropean Journal of Cancer
Volume37
Issue number15
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Keywords

  • Familial history
  • First-degree relative
  • Follow-up study
  • Second cancer
  • Seminoma
  • Teratoma
  • Testicular cancer

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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