Abstract
To report macular hole formation among siblings within four families. Observational case series. Four families were identified who had macular holes among siblings from within three multiphysician tertiary-care referral retina practices. In the first family, two sisters in their seventh decade developed Stage 2 macular holes requiring surgical intervention; two male siblings were unaffected. In a second family, three of four siblings were affected, including one brother with a Stage 4 macular hole, one sister with a Stage 3 macular hole, and a third sister with a lamellar macular hole. In a third family, two siblings (one man, one woman) developed macular holes within 1 year of each other. Three years later, the male sibling developed a macular hole in the fellow eye. In the last family, twin sisters developed macular holes (unilateral in one sister, bilateral in the other), and their deceased father may also have had bilateral macular holes. The occurrence of macular holes in these four sets of siblings suggests a possible genetic component in the formation of macular holes in these individuals.
| Original language | English |
|---|---|
| Pages (from-to) | 608-611 |
| Number of pages | 4 |
| Journal | American Journal of Ophthalmology |
| Volume | 138 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 1 2004 |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Familial idiopathic macular hole. / Lalin, Sean C.; Chang, Stanley; Flynn, Harry W; Von Fricken, Manfred; Del Priore, Lucian V.
In: American Journal of Ophthalmology, Vol. 138, No. 4, 01.10.2004, p. 608-611.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Familial idiopathic macular hole
AU - Lalin, Sean C.
AU - Chang, Stanley
AU - Flynn, Harry W
AU - Von Fricken, Manfred
AU - Del Priore, Lucian V.
PY - 2004/10/1
Y1 - 2004/10/1
N2 - To report macular hole formation among siblings within four families. Observational case series. Four families were identified who had macular holes among siblings from within three multiphysician tertiary-care referral retina practices. In the first family, two sisters in their seventh decade developed Stage 2 macular holes requiring surgical intervention; two male siblings were unaffected. In a second family, three of four siblings were affected, including one brother with a Stage 4 macular hole, one sister with a Stage 3 macular hole, and a third sister with a lamellar macular hole. In a third family, two siblings (one man, one woman) developed macular holes within 1 year of each other. Three years later, the male sibling developed a macular hole in the fellow eye. In the last family, twin sisters developed macular holes (unilateral in one sister, bilateral in the other), and their deceased father may also have had bilateral macular holes. The occurrence of macular holes in these four sets of siblings suggests a possible genetic component in the formation of macular holes in these individuals.
AB - To report macular hole formation among siblings within four families. Observational case series. Four families were identified who had macular holes among siblings from within three multiphysician tertiary-care referral retina practices. In the first family, two sisters in their seventh decade developed Stage 2 macular holes requiring surgical intervention; two male siblings were unaffected. In a second family, three of four siblings were affected, including one brother with a Stage 4 macular hole, one sister with a Stage 3 macular hole, and a third sister with a lamellar macular hole. In a third family, two siblings (one man, one woman) developed macular holes within 1 year of each other. Three years later, the male sibling developed a macular hole in the fellow eye. In the last family, twin sisters developed macular holes (unilateral in one sister, bilateral in the other), and their deceased father may also have had bilateral macular holes. The occurrence of macular holes in these four sets of siblings suggests a possible genetic component in the formation of macular holes in these individuals.
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U2 - 10.1016/j.ajo.2004.06.013
DO - 10.1016/j.ajo.2004.06.013
M3 - Article
C2 - 15488788
AN - SCOPUS:7044227792
VL - 138
SP - 608
EP - 611
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 4
ER -