Familial aggregation of lymphoplasmacytic lymphoma/Waldenström macroglobulinemia with solid tumors and myeloid malignancies

Sigurdur Y. Kristinsson, Lynn R. Goldin, Ingemar Turesson, Magnus Björkholm, Ola Landgren

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Lymphoplasmacytic lymphoma (LPL)/Waldenström macroglobulinemia (WM) is a B-cell disorder resulting from the accumulation, predominantly in the bone marrow, of clonally related lymphoplasmacytic cells. LPL/WM is a very rare disease, with an incidence rate of 3-4 cases per million people per year.Currently, the causes of LPL/WM are poorly understood; however, there are emerging data to support a role for immune-related factors in the pathogenesis of LPL/WM. In addition, data show that genetic factors are of importance in the etiology of LPL/WM. In this paper, we will review the current knowledge about familiality of LPL/WM and provide novel data on solid tumors and myeloid malignancies in first-degree relatives of LPL/WM patients.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalActa Haematologica
Volume127
Issue number3
DOIs
StatePublished - Mar 2012
Externally publishedYes

Keywords

  • Autoimmunity
  • Familial aggregation
  • Hematological malignancies
  • Lymphoplasmacytic lymphoma/Waldenström macroglobulinemia
  • Monoclonal gammopathy of undetermined significance
  • Solid tumors
  • Susceptibility

ASJC Scopus subject areas

  • Hematology

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